Maturation of cortical sound processing as indexed by event-related potentials
Maturation of cortical sound processing as indexed by event-related potentials
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DOI：
10.1016/s1388-2457(02)00078-0
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发表时间：
2002-06-01
影响因子：
4.7
通讯作者：
Näätänen, R
中科院分区：
文献类型：
--
作者：
Ceponiene, R;Rinne, T;Näätänen, R
目的：儿童听觉事件相关电位（ERPs）主要以P1和N2峰为主，而N1波出现在3 ~ 4岁。神经基板和行为相关的延长N1成熟，以及10年的N2的长期优势还不清楚。本研究利用高分辨率脑电图研究了4岁至成人听觉ERP的成熟过程，并比较了9岁儿童和成人的N1和N2峰的来源。三个部分谐波音分别以短（700 ms）和长结果：在短SOA条件下，4岁和9岁儿童出现P1和N2峰。而成人则表现为P1、N1、P2和N2波。在长SOA的情况下，9岁儿童也显示出NI峰，其在头皮分布上与成年人显示出P1、N1和P2峰的情况相反。在过滤掉缓慢的N2活动后，9岁儿童的短SOA数据中也显示了N1波，但4岁儿童没有。在成人和9岁儿童中，N2和N1的神经源映射到颞叶的上级方面。结论：儿童N1和成人N2的来源不同，儿童N1和成人N2的来源也不同。一个持久的个体发育的N1可能与听觉敏感性和定向，而PI和N2峰建议反映听觉感觉过程。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Objectives: Children's auditory event-related potentials (ERPs) are dominated by the P1 and N2 peaks, while the N1 wave emerges between 3 and 4 years of age. The neural substrates and the behavioral correlates of the protracted N1 maturation, as well as of the 10-year long predominance of the N2 are unclear. The present study utilized high-resolution electroencephalography to study the maturation of auditory ERPs from age 4 to adulthood and to compare the sources of the N1 and the N2 peaks in 9-year-old children and adults.Methods: Three partial harmonic tones were delivered with short (700 ms) and long (mean of 5 s) stimulus onset asynchrony (SOA), with only 700 ms SOA used with 4-year-olds.Results: With a short SOA, 4- and 9-year-old children displayed P1 and N2 peaks. whereas adults showed P1, N1, P2, and N2 waves. With a long SOA, 9-year-olds also displayed an NI peak, which was frontal in scalp distribution to that in adults who showed P1, N1, and P2 peaks. After filtering out the slow N2 activity, the N1 wave was also revealed in the short-SOA data in 9-year-old but not in 4-year-old children. In adults and in 9-year-olds, the neural sources of the N2 and N1 mapped onto the superior aspects of the temporal lobes. the sources of the N2 being anterior to those of the N1.Conclusions: The results indicated that children's N1 is composed of differently weighted components as that in adults, and that in both children and adults the N1 and N2 are generated by anatomically distinct generators. A protracted ontogeny of the N1 could be linked with that of auditory sensitivity and orienting, whereas the P I and N2 peaks are suggested to reflect auditory sensory processes. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.