3D-printed Quake-style microvalves and micropumps.
3D-printed Quake-style microvalves and micropumps.
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DOI：
10.1039/c8lc00001h
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发表时间：
2018-04-17
期刊：
影响因子：
6.1
通讯作者：
Folch A
中科院分区：
文献类型：
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作者：
Lee YS;Bhattacharjee N;Folch A
在这里，我们展示了一个3D打印的微型阀，它是透明的，由生物相容性树脂制成，并且具有简单的结构，可以很容易地扩展到大型阵列。静止时打开的阀门设计源自Quake的PDMS阀门设计。我们使用立体光刻（SL）3D打印机打印薄（25或10 μ m厚）膜（1200或500 μ m直径）。在碗状阀座上被反复按压（~3-6 psi）以关闭阀门。我们使用聚（乙烯二丙烯酸酯）（MW = 258）（PEG-DA-258）作为树脂，因为它产生透明的细胞相容性打印。尽管PEG-DA-258的柔性不如其他微阀制造材料（例如PDMS）的柔性，但阀受益于碗设计和膜的高恢复力，因为它不需要负压来重新打开。我们还通过串联三个螺旋式阀门来3D打印微型泵。微型泵的运行仅需要正压，并从快速返回到阀门的打开状态中获益。此外，我们还打印了一个直径为500 μ m的64阀阵列。阀门，以证明阀门的可靠性和可扩展性。总的来说，我们展示了紧凑型微型阀和微型泵的3D打印，使用的过程排除了对专业化，耗时劳动力的需求。
Here we demonstrate a 3D-printable microvalve that is transparent, built with a biocompatible resin, and has a simple architecture that can be easily scaled up into large arrays. The open-at-rest valve design is derived from Quake’s PDMS valve design. We used a stereolithographic (SL) 3D printer to print a thin (25 or 10 μm-thick) membrane (1200 or 500 μm-diam.) that is pneumatically pressed (~3–6 psi) over a bowl-shaped seat to close the valve. We used poly(ethylene diacrylate) (MW = 258) (PEG-DA-258) as the resin because it yields transparent cytocompatible prints. Although the flexibility of PEG-DA-258 is inferior to that of other microvalve fabrication materials such as PDMS, the valve benefits from the bowl design and the membrane’s high restoring force since it does not need a negative pressure to re-open. We also 3D-printed a micropump by combining three Quake-style valves in series. The micropump only requires positive pressure for its operation and profits from the fast return to the valves’ open states. Moreover, we printed a 64-valve array constructed with 500 μm-diam. valves to demonstrate the reliability and scalability of the valves. Overall, we demonstrate the 3D-printing of compact microvalves and micropumps using a process that precludes the need for specialized, time-consuming labor.