RIG-I in RNA virus recognition.
RIG-I in RNA virus recognition.
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DOI：
10.1016/j.virol.2015.02.017
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发表时间：
2015-05
期刊：
影响因子：
3.7
通讯作者：
Gale, Michael, Jr.
中科院分区：
文献类型：
--
作者：
Kell, Alison M.;Gale, Michael, Jr.
抗病毒免疫是在宿主通过病原体相关分子模式(PAMPs)识别病毒产物时启动的。这种识别启动了信号级联反应，诱导细胞内的天然免疫防御和促进获得性免疫反应发展的炎症反应。视黄酸诱导基因I(RIG-I)和RIG-I样受体(RLR)蛋白家族是重要的细胞质病原体识别受体，参与跨属和跨病毒家族的病毒识别，包括作为RNA病毒的主要感受器和促进某些DNA病毒的识别。RIG-I是RLR家族的创始成员，在与PAMP RNA结合后被激活。RIG-I通过与适配蛋白MAVS相互作用激活RIG-I信号，导致信号级联激活转录因子IRF3和NF-κB。这些作用诱导抗病毒基因产物的表达以及I型和III型干扰素的产生，从而在感染细胞和周围组织中导致抗病毒状态。RIG-I信号对于控制许多RNA病毒的感染是必不可少的。最近，RIG-I与其他病原体识别受体和炎症体组件的串扰已被描述。在这篇综述中，我们讨论了关于RIG-I在识别各种病毒家族中的作用以及它通过与先天性免疫系统的平行臂的串扰而在编程适应性免疫反应中的作用的现有知识，包括如何利用RIG-I进行抗病毒治疗。RIG-I是一种胞质病原体识别受体。RIG-I与PAMP RNA结合。RIG-I启动对RNA病毒感染的免疫反应。
Antiviral immunity is initiated upon host recognition of viral products via non-self molecular patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition initiates signaling cascades that induce intracellular innate immune defenses and an inflammatory response that facilitates development of the acquired immune response. The retinoic acid-inducible gene I (RIG-I) and the RIG-I-like receptor (RLR) protein family are key cytoplasmic pathogen recognition receptors that are implicated in the recognition of viruses across genera and virus families, including functioning as major sensors of RNA viruses, and promoting recognition of some DNA viruses. RIG-I, the charter member of the RLR family, is activated upon binding to PAMP RNA. Activated RIG-I signals by interacting with the adapter protein MAVS leading to a signaling cascade that activates the transcription factors IRF3 and NF-κB. These actions induce the expression of antiviral gene products and the production of type I and III interferons that lead to an antiviral state in the infected cell and surrounding tissue. RIG-I signaling is essential for the control of infection by many RNA viruses. Recently, RIG-I crosstalk with other pathogen recognition receptors and components of the inflammasome has been described. In this review, we discuss the current knowledge regarding the role of RIG-I in recognition of a variety of virus families and its role in programming the adaptive immune response through cross-talk with parallel arms of the innate immune system, including how RIG-I can be leveraged for antiviral therapy. RIG-I is a cytosolic pathogen recognition receptor. RIG-I binds to PAMP RNA. RIG-I initiates the immune response to RNA virus infection.
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影响因子：
3.7
作者：
Burke, Crystal W.;Gardner, Christina L.;Steffan, Joshua J.;Ryman, Kate D.;Klimstra, William B.
通讯作者：
Klimstra, William B.
SARS冠状病毒木瓜蛋白酶样蛋白酶通过与STING-TRAF3-TBK1复合物相互作用抑制I型干扰素信号通路
影响因子：
21.1
作者：
Chen, Xiaojuan;Yang, Xingxing;Zheng, Yang;Yang, Yudong;Xing, Yaling;Chen, Zhongbin
通讯作者：
Chen, Zhongbin
影响因子：
5.4
作者：
Errett, John S.;Suthar, Mehul S.;Gale, Michael, Jr.
通讯作者：
Gale, Michael, Jr.
影响因子：
5.4
作者：
Alff, Peter J.;Gavrilovskaya, Irina N.;Mackow, Erich R.
通讯作者：
Mackow, Erich R.
DOI：
10.1073/pnas.220398297
发表时间：
2000-10-24
影响因子：
11.1
作者：
Basler, CF;Wang, XY;Palese, P
通讯作者：
Palese, P