Increased 24-h energy expenditure in type-2 diabetes
Increased 24-h energy expenditure in type-2 diabetes
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DOI：
10.2337/diacare.27.10.2416
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发表时间：
2004-10-01
期刊：
影响因子：
16.2
通讯作者：
Astrup, A
中科院分区：
文献类型：
--
作者：
Bitz, C;Toubro, S;Astrup, A
目的-本研究的目的是确定是否超重和肥胖的2型糖尿病患者有较高的基础和24小时能量消耗与健康对照组相比，调整身体成分，自发体力活动（SPA），性别和age.Research设计和方法-数据从31例2型糖尿病和61非糖尿病对照组进行了分析。在全身呼吸室中测量24小时能量消耗、基础代谢率（BMR）和1：00 A.M.至6：00 A.M.之间的睡眠能量消耗（EEsleep）。身体成分进行了评估，通过双能X线吸收仪（DXA）。结果-未调整的EE睡眠，BMR，和24小时能量消耗2型糖尿病组和对照组之间没有显着差异。在调整了无脂体重（FFM）、脂肪量、SPA、性别和年龄后，2型糖尿病组的EEsleep和BMR分别比对照组高7.7%和6.9%。这分别相当于144+/-40千卡/天（P = 0.0001）和139+/-61千卡/天（P = 0.0026）。2型糖尿病组校正后的24小时能量消耗比非糖尿病对照组高6.5%（2.679+/-37 vs 2，515 +/-23 kcal/day，P = 0.0002）。在多元回归分析中，FFM，脂肪量，SPA和糖尿病状态都是EE睡眠和24小时能量消耗的重要决定因素，分别解释了83%和81%的变异，结论-这项研究证实了皮马印第安人的报告，基础和24小时能量消耗调整身体成分，SPA，性别，与非糖尿病对照受试者相比，2型糖尿病患者的年龄和性别差异更大，在高加索人中甚至更明显。
OBJECTIVE - The aim of this study was to determine whether overweight and obese individuals with type 2 diabetes have higher basal and 24-h energy expenditure compared with healthy control subjects before and after adjustment for body composition, spontaneous physical activity (SPA), sex, and age.RESEARCH DESIGN AND METHODS - Data from 31 subjects with type 2 diabetes and 61 nondiabetic control subjects were analyzed. The 24-h energy expenditure, based metabolic rate (BMR), and sleeping energy expenditure (EEsleep) between 1:00 A.M and 6:00 A.M. were measured in whole-body respiratory chambers. Body composition was assessed by dual-energy X-ray absorptiometry (DXA).RESULTS - No significant differences in unadjusted EEsleep, BMR, and 24-h energy expenditure were observed between the type 2 diabetic group and the control group. After adjustment for fat-free mass (FFM), fat mass, SPA, sex, and age, EEsleep and BMR were respectively, 7.7 and 6.9% higher in the type 2 diabetic group compared with the control group. This was equivalent to 144+/-40 kcal/day (P = 0.0001) and 139+/-61 kcal/day (P = 0.0026), respectively. Adjusted 24-h energy expenditure was 6.5% higher in the type 2 diabetic group compared with the nondiabetic control subjects (2.679+/-37 vs 2,515+/-23 kcal/day, P = 0.0002). In multiple regression analyses, FFM, fat mass, SPA, and diabetes status were all significant determinants of EEsleep and 24-h energy expenditure explaining 83 and 81% of the variation, respectively.CONCLUSIONS - This study confirms reports in Pima Indians that basal and 24-h energy expenditure adjusted for body composition, SPA, sex, and age are higher in individuals with type 2 diabetes compared with nondiabetic control subjects and may be even more pronounced in Caucasians.