Effects of ketamine and propofol on autonomic cardiovascular function in chronically instrumented rats
Effects of ketamine and propofol on autonomic cardiovascular function in chronically instrumented rats
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DOI：
10.1016/s1566-0702(00)00271-x
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发表时间：
2001-03-23
影响因子：
2.7
通讯作者：
Kato, Y
中科院分区：
文献类型：
--
作者：
Akine, A;Suzuka, H;Kato, Y
在本研究中，我们系统地研究了氯胺酮和异丙酚在不同剂量（5 - 20 mg/kg）对血压，心率和肾交感神经活动的影响。我们还评估了这些麻醉剂对心率和肾交感神经活动的压力反射控制的影响。氯胺酮（10 mg/kg）使血压升高30.0 ± 4.5%，心率升高17.7 ± 3.3%，肾交感神经活性升高38.8 ± 14.6%，而丙泊酚（10 mg/kg）使血压降低18.9 ± 3.5%，心率降低5.5 ± 2.5%，肾交感神经活性降低7.5 ± 2.1%。这些变量显示对两种药物的剂量依赖性反应。氯胺酮和丙泊酚均降低了平均血压与心率和血压与肾交感神经活动相关的logistic函数曲线的范围和最大增益。结论：氯胺酮和丙泊酚对自主心血管功能有不同的影响，但对心率的压力反射敏感性和肾交感神经活动有剂量依赖性的减弱作用。这些结果提示压力反射敏感性可能反映麻醉深度。(C)2001 Elsevier Science B.V.保留所有权利。
In this study, we systematically examined the effects of ketamine and propofol at various doses (5-20 mg/kg) on blood pressure, heart rate and renal sympathetic nerve activity in chronically instrumented Wistar rats. We also assessed the effects of these anesthetics on the baroreflex control of heart rate and renal sympathetic nerve activity. Ketamine (10 mg/kg) increased blood pressure by 30.0+/-4.5%, heart rate by 17.7+/-3.3% and renal sympathetic nerve activity by 38.8+/-14.6%, while propofol (10 mg/kg) decreased blood pressure by 18.9+/-3.5%, heart rate by 5.5+/-2.5% and renal sympathetic nerve activity by 7.5+/-2.1%. These variables showed dose-dependent responses to both agents. Both ketamine and propofol decreased the range and maximum gain of the logistic function curve obtained by relating mean blood pressure to heart rate and blood pressure to renal sympathetic nerve activity. In conclusion, ketamine and propofol had different effects on autonomic cardiovascular function, but attenuated the baroreflex sensitivity of heart rate and renal sympathetic nerve activity in a dose-dependent manner. These results suggest the possibility that baroreflex sensitivity may reflect the depth of anesthesia. (C) 2001 Elsevier Science B.V. All rights reserved.