A sex difference in the rat pituitary FSH response to unilateral gonadectomy as revealed in plasma radioimmunoassays.
A sex difference in the rat pituitary FSH response to unilateral gonadectomy as revealed in plasma radioimmunoassays.
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血浆放射免疫测定揭示了大鼠垂体 FSH 对单侧性腺切除反应的性别差异。
作者：
V. Ramirez;C. Sawyer
将青春期前和成年雌性和雄性大鼠单侧性腺切除，并在6天后处死，以确定代偿性卵巢（COH）或睾丸（CTH）肥大的程度。手术后不同时间在乙醚浅麻醉下，抽取颈外静脉血，用放射免疫法测定FSH和LEI。单侧睾丸切除术后，由一个明确的CTH和手术后2天的血液FSH浓度急剧增加，值保持在一个高水平的成人，但继续上升，在未成熟的动物。成年男性的血液LH水平没有显着变化。丙酸替卡松抑制CTH和血浆FSH的升高。在成年雌性大鼠单侧卵巢切除术的第一天的间情期，其次是一个短暂的急剧上升，血液FSH，值恢复到初始水平，手术后36小时，此后波动这些水平。在FSH升高后开始的乙烯利处理抑制COH，但血FSH和LH水平与对照组相似。
Prepubertal and adult female and male rats were unilaterally gonadectomized and killed 6 days later to determine the degree of compensatory ovarian (COH) or testicular (CTH) hypertrophy. External jugular vein blood was drawn, under light ether anesthesia at different times after surgery, for radioimmunoassay of FSH and LEI. Unilateral orchidectomy was followed by a clear-cut CTH and by sharp increases in blood FSH concentration 2 days after the operation, values which remained at a high level in adults but continued to rise in immature animals. Blood LH levels in adult males did not change significantly. Testosterone propionate inhibited CTH and the rise in plasma FSH. In adult female rats unilateral ovariectomy on the first day of diestrus was followed by a transient sharp rise in blood FSH, values that returned to initial levels by 36 hr post-surgery and thereafter fluctuated about these levels. Estradiol berizoate treatment, starting after the rise in FSH, inhibited COH, but blood FSH and LH levels par...