Investigation of diffuse correlation spectroscopy in multi-layered media including the human head
Investigation of diffuse correlation spectroscopy in multi-layered media including the human head
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DOI：
10.1364/oe.16.015514
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发表时间：
2008-09-29
期刊：
影响因子：
3.8
通讯作者：
Lesage, Frederic
中科院分区：
文献类型：
--
作者：
Gagnon, Louis;Desjardins, Michele;Lesage, Frederic
在这项工作中，扩散相关光谱（DCS）的多层几何形状进行了探索。定量比较的均匀与两层模型的效率，以恢复流量的变化。通过模拟一个现实的人的头部与MRI解剖数据，我们表明，两层模型可以区分在表层和大脑的变化。我们还表明，两层模型提供了一个更好的估计比均匀的流量变化。实验测量与两层的动态幻影确认的能力，两层的分析模型，以区分流量增加，在每一层。(C)2008年美国光学学会
In this work, diffuse correlation spectroscopy (DCS) is explored in multi-layered geometries. A quantitative comparison of an homogeneous versus a two-layered model efficiencies to recover flow changes is presented. By simulating a realistic human head with MRI anatomical data, we show that the two-layered model allows distinction between changes in superficial layers and brain. We also show that the two-layered model provides a better estimate of the flow change than the homogeneous one. Experimental measurements with a two-layered dynamical phantom confirm the ability of the two-layered analytical model to distinguish flow increase in each layer. (C) 2008 Optical Society of America