Epigenetic landscape and miRNA involvement during neural crest development.
Epigenetic landscape and miRNA involvement during neural crest development.
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神经嵴发育过程中的表观遗传景观和 miRNA 参与。
DOI：
10.1002/dvdy.23868
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Buzzi,Ailin
中科院分区：
文献类型：
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作者：
Strobl-Mazzulla,PabloH;Marini,Melisa;Buzzi,Ailin
神经嵴（NC）是脊椎动物胚胎背侧神经褶中产生的多能迁移细胞群。NC细胞广泛迁移并分化成各种组织，包括黑素细胞、骨和颅面骨骼的软骨、外周和肠神经元、神经胶质以及平滑肌和内分泌细胞。多年来，已经广泛研究了协调NC细胞发育的基因调控网络。然而，我们最近开始了解，表观遗传和转录后调控，如miRNA，在NC的发展中发挥重要作用。在这篇综述中，我们重点介绍了一些最新的研究结果，在脊椎动物NC细胞发育过程中的染色质依赖性机制和miRNA的调控。发展动力学，2012年。© 2012 Wiley Periodicals，Inc.
The neural crest (NC) is a multipotent, migratory cell population that arises from the dorsal neural fold of vertebrate embryos. NC cells migrate extensively and differentiate into a variety of tissues, including melanocytes, bone, and cartilage of the craniofacial skeleton, peripheral and enteric neurons, glia, and smooth muscle and endocrine cells. For several years, the gene regulatory network that orchestrates NC cells development has been extensively studied. However, we have recently begun to understand that epigenetic and posttranscriptional regulation, such as miRNAs, plays important roles in NC development. In this review, we focused on some of the most recent findings on chromatin‐dependent mechanisms and miRNAs regulation during vertebrate NC cells development. Developmental Dynamics, 2012. © 2012 Wiley Periodicals, Inc.