Characterization of Biodegradable Polyurethane Nanoparticles and Thermally Induced Self-Assembly in Water Dispersion
Characterization of Biodegradable Polyurethane Nanoparticles and Thermally Induced Self-Assembly in Water Dispersion
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DOI：
10.1021/am500213t
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发表时间：
2014-04-23
影响因子：
9.5
通讯作者：
Hsu, Shan-hui
中科院分区：
文献类型：
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作者：
Ou, Chun-Wei;Su, Chiu-Hun;Hsu, Shan-hui
本研究将具有不同组成的可生物降解低聚二醇作为软链段的水性聚氨酯（PU）合成为纳米颗粒（NP）。使用动态光散射（DLS）、多角度光散射（MALS）、透射电子显微镜（TEM）和小角X射线散射（SAXS），我们证明这些纳米颗粒是具有不同形状因子的致密球体。 PU NP 在水中的温度依赖性膨胀是明显的。特别是，以 80 mol% 聚己内酯 (PCL) 二醇和 20 mol% 聚（L-丙交酯）（PLLA）二醇作为软链段的 PU NP 在 37 ℃ 下具有显着的溶胀（类似于 450%）。这伴随着 NP 分散体在约 2 分钟内观察到的溶胶-凝胶转变。这些纳米粒子的热诱导膨胀和自组装与二次力（主要是氢键）和结晶度有关，这取决于软链段的组成。 PU NP 与混合可生物降解低聚二醇的热响应性可用于设计智能可生物降解载体，用于在接近体温的情况下递送细胞或药物。
Waterborne polyurethanes (PU) with different compositions of biodegradable oligodiols as the soft segment were synthesized as nanoparticles (NPs) in this study. Using dynamic light scattering (DLS), multiangle light scattering (MALS), transmission electron microscopy (TEM), and small-angle X-ray scattering (SAXS), we demonstrated that these NPs were compact spheres with different shape factors. The temperature-dependent swelling of the PU NPs in water was distinct. In particular, PU NPs with 80 mol % polycaprolactone (PCL) diol and 20 mol % poly(L-lactide) (PLLA) diol as the soft segment had significant swelling (similar to 450%) at 37 degrees C. This was accompanied by a sol-gel transition observed in about 2 min for the NP dispersion. The thermally induced swelling and self-assembly of these NPs were associated with the secondary force (mainly hydrogen bonding) and degree of crystallinity, which depended on the soft segment compositions. The thermo-responsiveness of the PU NPs with mixed biodegradable oligodiols may be employed to design smart biodegradable carriers for delivery of cells or drugs near body temperature.