New clinical test of retinal function based upon the standing potential of the eye.
New clinical test of retinal function based upon the standing potential of the eye.
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DOI：
10.1136/bjo.46.8.449
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发表时间：
1962-08-01
期刊：
影响因子：
--
通讯作者：
Kelsey, J H
中科院分区：
文献类型：
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作者：
Arden, G B;Barrada, A;Kelsey, J H
视网膜代谢的客观测试451站立电位变化的描述（1）自发变化。已经描述了短期和长期的周期性变化。后者构成了电位日变化的一部分（Kris，1960），我们不必进一步关注，因为在短的记录期间，由这一原因引起的波动是微不足道的。然而，无论何时测量驻电位，电位振幅的周期性变化都以大约半小时为周期发生（Kolder，1959）。随着记录过程的继续，波的振幅减小，通常在大约两个小时后达到基线水平。这些波动可能不是真正自发的（见下文），重要性仅在于它们掩盖了基线电位，其值与视网膜照明无关（Kolder，1959）。(2)光照变化对驻极体电位大小的影响当暗适应的视网膜被重新照亮时，会发生一系列复杂的驻电位变化。这些在图1中示出。首先出现视网膜电图，但这种快速的电位变化在图中并不明显，图中显示的是慢得多的事件。第一个变化是一个短暂的下降（a），但在约90秒后。潜力开始上升。这持续约8-9分钟，当电位达到峰值（B）时，这个最大值被命名为第一个光峰。在28 B中，
OBJECTIVE TEST OF RETIANAL METABOLISM 451 Description of Variations in the Standing Potential (1) Spontaneous Variations.-Both short and long term cyclical variations have been described. The latter form part of the diurnal variation of potential (Kris, 1960) and need not concern us further since during short recording periods fluctuations from this cause are insignificant. However, whenever the standing potential is measured, cyclical variations in the amplitude ofthe potential occur with a period of about half an hour (Kolder, 1959). As the recording session continues the amplitude of the waves decreases and a baseline level is reached, usually after about two hours. These fluctuations are probably not truly spontaneous (see below) and are of importance only in that they obscure the baseline potential, the value of which is independent of the retinal illumination (Kolder, 1959).(2) Influence of Change of Illuminationon the Magnitude of the Standing Potential.-When the dark-adapted retina is reilluminated, a complex sequence of alterations in the standing potential occurs. These are demonstrated in Fig. 1. There first occurs an electroretinogram, but this rapid potential change is not apparent in the Figure, which shows very much slower events. The first change in the standing potential is a transient fall (a), but after about 90 sec. the potential begins to rise. This continues for about 8-9 min., when the potential reaches a peak (b). This maximum has been named the first light peak. It is relatively constant in amplitude and in28 b