GLOBAL ANALYSIS OF GENES INVOLVED IN FRESHWATER ADAPTATION IN THREESPINE STICKLEBACKS (GASTEROSTEUS ACULEATUS)
GLOBAL ANALYSIS OF GENES INVOLVED IN FRESHWATER ADAPTATION IN THREESPINE STICKLEBACKS (GASTEROSTEUS ACULEATUS)
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DOI：
10.1111/j.1558-5646.2011.01247.x
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发表时间：
2011-06-01
期刊：
影响因子：
3.3
通讯作者：
Merila, Juha
中科院分区：
文献类型：
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作者：
DeFaveri, Jacquelin;Shikano, Takahito;Merila, Juha
在三刺棘鱼（Gasterosteus aculeatus）的全球分布中，表型特征平行进化的例子已被反复证明。利用这些模型，我们进行了有针对性的基因组扫描——聚焦于可能与淡水适应相关的生理重要基因——以识别全球范围内平行生理进化的遗传特征。为此，从北半球6个地点成对的海洋和淡水种群中筛选了50个微卫星位点，其中包括26个位于或接近（< 6 kb）生理重要基因的位点。在至少一个位置检测到24个位点（包括17个生理上重要的基因）的方向选择特征。虽然没有位点在所有不同的种群对中表现出一致的选择特征，但在多个地点有几个异常值是常见的。特别是，7个生理上重要的基因，以及参考外胞质异常蛋白基因（EDA），在三个或更多的位置上表现出选择的特征。因此，尽管这些结果为响应淡水定植的一致平行分子进化提供了一些证据，但它们表明，在三刺鱼全球分布的淡水栖息地中，不同的进化途径可能是生理适应的基础。
Examples of parallel evolution of phenotypic traits have been repeatedly demonstrated in threespine sticklebacks (Gasterosteus aculeatus) across their global distribution. Using these as a model, we performed a targeted genome scan-focusing on physiologically important genes potentially related to freshwater adaptation-to identify genetic signatures of parallel physiological evolution on a global scale. To this end, 50 microsatellite loci, including 26 loci within or close to (< 6 kb) physiologically important genes, were screened in paired marine and freshwater populations from six locations across the Northern Hemisphere. Signatures of directional selection were detected in 24 loci, including 17 physiologically important genes, in at least one location. Although no loci showed consistent signatures of selection in all divergent population pairs, several outliers were common in multiple locations. In particular, seven physiologically important genes, as well as reference ectodysplasin gene (EDA), showed signatures of selection in three or more locations. Hence, although these results give some evidence for consistent parallel molecular evolution in response to freshwater colonization, they suggest that different evolutionary pathways may underlie physiological adaptation to freshwater habitats within the global distribution of the threespine stickleback.