Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population
Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population
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DOI：
10.1126/science.1073420
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发表时间：
2002-10-04
期刊：
影响因子：
56.9
通讯作者：
Vernick, KD
中科院分区：
文献类型：
--
作者：
Niaré, O;Markianos, K;Vernick, KD
疟疾寄生虫恶性疟原虫在易感蚊子载体内成功繁殖是疟疾传播的先决条件。对主要的人类疟疾病媒冈比亚按蚊进行的实地遗传分析揭示了减少恶性疟原虫传播的自然因素。喂养相同感染血液的蚊子同雌家庭之间恶性疟原虫卵囊数量的差异表明影响对寄生虫的抗性的大的遗传成分，并且野生蚊子谱系中的全基因组扫描检测到分离的抗性等位基因。抗性等位基因的自然频率明显较高，表明疟原虫（或类似病原体）对病媒种群施加了重大的选择压力。
Successful propagation of the malaria parasite Plasmodium falciparum within a susceptible mosquito vector is prerequisite for the transmission of malaria. A field-based genetic analysis of the major human malaria vector, Anopheles gambiae, has revealed natural factors that reduce the transmission of P. falciparum. Differences in P. falciparum oocyst numbers between mosquito isofemale families fed on the same infected blood indicated large genetic component affecting resistance to the parasite, and genome-wide scanning in pedigrees of wild mosquitoes detected segregating resistance alleles. The apparently high natural frequency of resistance alleles suggests that malaria parasites (or similar pathogen) exert significant selective pressure on vector populations.