Epidermal Langerhans cell involvement in cutaneous lupus erythematosus.
Epidermal Langerhans cell involvement in cutaneous lupus erythematosus.
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表皮朗格汉斯细胞参与皮肤红斑狼疮。
DOI：
10.1111/1523-1747.ep12500069
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Bergstresser,PR
中科院分区：
文献类型：
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作者：
Sontheimer,RD;Bergstresser,PR
表皮朗格汉斯细胞（LC）具有表面标志物和功能属性，将其鉴定为巨噬细胞/单核细胞谱系，最近的证据证明它们参与皮肤中发生的某些免疫过程。为了评估LC在以免疫系统功能障碍为主的红斑狼疮（LE）中的作用，用3种LC表面标志物：ATP酶活性、HLA-DR和OKT-6抗原研究了皮肤LE患者的人表皮。3种临床类型的皮肤LE患者的抽吸水疱顶部表皮皮肤活检表现出相似的特征：LC较少树突状，它们更不规则地分布，并且与邻近正常皮肤相比，它们的数量较少。这些变化与在具有类似苔藓样组织病理学特征的疾病中观察到的变化形成对比。扁平苔藓中LC数量增多。一名皮肌炎患者皮损中的LC表现出相似的形态学改变，但表面密度和分布保持不变。皮肤LE患者皮损处的解聚表皮细胞诱导同种异体淋巴细胞增殖的效率与非皮损皮肤的细胞一样高，表明观察到的形态学改变与同种异体抗原提呈能力降低无关。这些研究表明，表皮LC人口在3种临床类型的皮肤LE的干扰的方式没有看到在其他2苔藓样皮肤疾病，虽然这些变化与改变能力的细胞刺激同种异体淋巴细胞增殖。
Epidermal Langerhans cells (LCs) possess surface markers and functional attributes which identify them as being of macrophage/monocyte lineage, and recent evidence documents their participation in certain immune process which occur in skin. To assess the role of LCs in lupus erythematosus (LE), a disease in which immune system dysfunction predominates, human epidermis from patients with cutaneous LE was studied with 3 LC surface markers: ATPase activity, HLA-DR and OKT-6 antigens. Suction blister top epidermal skin biopsies from patients with 3 clinical types of cutaneous LE exhibited similar features: LCs were less dendritic, they were more irregularly distributed, and they were present in fewer numbers when compared with those in adjacent normal skin. These changes contrasted with those observed in diseases with similar lichenoid histopathological features. LCs appeared increased in number in lichen planus. LCs in skin lesions from one patient with dermatomyositis exhibited similar morphologic alterations, but surface densities and distributions were preserved. Disaggregated epidermal cells from skin lesions of patients with cutaneous LE induced allogeneic lymphocyte proliferation as efficiently as did cells from nonlesional skin, indicating that the morphologic alterations observed were not associated with a decreased alloantigen presenting capacity. These studies have demonstrated that epidermal LC populations in 3 clinical types of cutaneous LE are perturbed in a manner not seen in 2 other lichenoid skin diseases, although these changes were not associated with an altered capacity of such cells to stimulate proliferation by allogeneic lymphocytes.