Insulin-Like Growth Factor I Regulation and Its Actions in Skeletal Muscle.
Insulin-Like Growth Factor I Regulation and Its Actions in Skeletal Muscle.
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DOI：
10.1002/cphy.c180010
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发表时间：
2018-12
影响因子：
5.8
通讯作者：
Georgios Vassilakos;E. Barton
中科院分区：
文献类型：
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作者：
Georgios Vassilakos;E. Barton
胰岛素样生长因子（IGF）途径对于促进几乎所有组织的生长和存活至关重要。它与其相关蛋白胰岛素具有高度同源性，因此，这些分子之间在合成代谢和代谢功能方面存在相互作用。骨骼肌产生相当大比例的IGF-1，并对其作用高度敏感，包括增加肌肉质量和提高再生能力。在本概述中，将描述IGF-1在骨骼肌中的产生、稳定性和活性的调节。其次，将讨论产生的IGF-1形式的生理意义。最后，IGF-1与其他途径的相互作用将得到解决。© 2019美国生理学会。Compr Physiol 9：413-438，2019。
The insulin-like growth factor (IGF) pathway is essential for promoting growth and survival of virtually all tissues. It bears high homology to its related protein insulin, and as such, there is an interplay between these molecules with regard to their anabolic and metabolic functions. Skeletal muscle produces a significant proportion of IGF-1, and is highly responsive to its actions, including increased muscle mass and improved regenerative capacity. In this overview, the regulation of IGF-1 production, stability, and activity in skeletal muscle will be described. Second, the physiological significance of the forms of IGF-1 produced will be discussed. Last, the interaction of IGF-1 with other pathways will be addressed. © 2019 American Physiological Society. Compr Physiol 9:413-438, 2019.