Introduction to 'steroid hormone actions in the CNS: the role of brain-derived neurotrophic factor (BDNF)'.
Introduction to 'steroid hormone actions in the CNS: the role of brain-derived neurotrophic factor (BDNF)'.
复制标题
介绍“类固醇激素在中枢神经系统中的作用：脑源性神经营养因子 (BDNF) 的作用”。
DOI：
10.1016/j.neuroscience.2012.10.022
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发表时间：
2013
期刊：
影响因子：
3.3
通讯作者：
Srivastava,DP
中科院分区：
文献类型：
--
作者：
Scharfman,HE;Kramár,EA;Luine,V;Srivastava,DP
Historically there have been many discussions of the growth-associated actions of estrogen, progesterone and androgen in the periphery based on their critical functions related to reproduction. For example, the initial surge in estrogen during the first stages of pregnancy is critical to the growth of the uterus, placenta and fetus. During each ovarian cycle, a surge in 17β-estradiol at the middle of each cycle leads to maturation of the ovarian follicle and its release from the ovary. The other gonadal steroids are equally as important in growth and growth-associated actions in peripheral tissues.What has become increasingly clear is that these same “reproductive” or “gonadal” steroids are also critical to the development of the CNS and the types of plasticity that occur in the adult CNS. For example, a neonatal surge in androgen in the male is converted to 17βestradiol and shapes the brain and behavior for the lifetime (Lenz et al., 2012). In puberty and adulthood, estrogen, progesterone and androgen modify neuronal and synaptic plasticity such as remodeling of the dendritic tree and synapse structure, generation of neurons in the adult hippocampus, and the suggested cellular correlate of learning–long-term potentiation (LTP)(Cooke and Woolley, 2005; Galea et al., 2008; Smith et al., 2009; Ooishi et al., 2012). Thus estrogen, progesterone and androgen influence diverse areas of the brain and spinal
