ASYMMETRIC-SYNTHESIS OF THE DIASTEREOISOMERS OF L-1-INDANYLGLYCINE AND L-1-BENZ[F]INDANYLGLYCINE, CHI-1-CHI-2-CONSTRAINED SIDE-CHAIN DERIVATIVES OF L-PHENYLALANINE AND L-2-NAPHTHYLALANINE
ASYMMETRIC-SYNTHESIS OF THE DIASTEREOISOMERS OF L-1-INDANYLGLYCINE AND L-1-BENZ[F]INDANYLGLYCINE, CHI-1-CHI-2-CONSTRAINED SIDE-CHAIN DERIVATIVES OF L-PHENYLALANINE AND L-2-NAPHTHYLALANINE
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DOI：
10.1016/0957-4166(92)80003-f
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发表时间：
1992-11-01
影响因子：
--
通讯作者：
CHASSAING, G
中科院分区：
文献类型：
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作者：
JOSIEN, H;CHASSAING, G
L-1-茚满基甘氨酸和L-1-苯并[f]茚满基甘氨酸的非对映异构体，新的地形工具和类似物的苯丙氨酸和2-萘基丙氨酸，从sultam衍生的甘氨酸亚胺合成子通过明智的亲电试剂烷基化，随后水解和sultam裂解合成。对一种烷基化产物的X射线分析确定了β-构型。
The diastereoisomers of L-1-indanylglycine and L-1-benz[f]indanylglycine, novel topographic tools and anologues of phenylalanine and 2-naphtylalanine, were synthesized from a sultam-derived glycine imine synthon alkylated by judicious electrophiles, and subsequent hydrolysis and sultam-cleavage. An X-ray analysis on one alkylation product established the beta-configuration.