Temporal dynamics of parvalbumin-expressing axo-axonic and basket cells in the rat medial prefrontal cortex in vivo.
Temporal dynamics of parvalbumin-expressing axo-axonic and basket cells in the rat medial prefrontal cortex in vivo.
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DOI：
10.1523/jneurosci.3475-12.2012
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发表时间：
2012-11-14
期刊：
影响因子：
--
通讯作者：
Klausberger T
中科院分区：
文献类型：
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作者：
Massi L;Lagler M;Hartwich K;Borhegyi Z;Somogyi P;Klausberger T
轴突-轴突中间神经元，专门支配轴突起始段，和小白蛋白表达篮中间神经元，靶向锥体细胞的胞体，树突和棘，已被提出控制神经元活动的前额叶回路。我们记录了麻醉大鼠前边缘皮层中识别出的神经元的尖峰时间，并表明在夹尾诱导的大脑状态激活期间，轴-轴细胞增加了它们的放电。此外，轴突-轴突细胞不同于其他GABA能小清蛋白表达细胞，其尖峰时间在缓慢振荡的向下到向上状态转换期间，以及其与γ和纺锤体振荡的耦合。轴-轴和其他表达小白蛋白的细胞的不同的放电动力学和突触靶点为前额叶网络的时间组织提供了不同的贡献。
Axo-axonic interneurons, innervating exclusively axon initial segments, and parvalbumin-expressing basket interneurons, targeting somata, dendrites, and spines of pyramidal cells, have been proposed to control neuronal activity in prefrontal circuits. We recorded the spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo-axonic cells increase their firing during tail pinch-induced brain state-activation. In addition, axo-axonic cells differ from other GABAergic parvalbumin-expressing cells in their spike timing during DOWN- to UP-state transitions of slow oscillations and in their coupling to gamma and spindle oscillations. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks.