The thymus-adrenal connection: thymosin has corticotropin-releasing activity in primates.
The thymus-adrenal connection: thymosin has corticotropin-releasing activity in primates.
复制标题
胸腺-肾上腺连接：胸腺素在灵长类动物中具有促肾上腺皮质激素释放活性。
DOI：
10.1126/science.6318312
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Goldstein,AL
中科院分区：
文献类型：
--
作者：
Healy,DL;Hodgen,GD;Schulte,HM;Chrousos,GP;Loriaux,DL;Hall,NR;Goldstein,AL
对青春期前食蟹猴静脉给药时，无内毒素胸腺素组分5以剂量和时间依赖的方式升高促肾上腺皮质激素、β-内啡肽和皮质醇。合成的两个胸腺肽组份5对垂体功能无急性影响，提示胸腺肽组份5的另一些多肽参与了促肾上腺皮质激素的释放活动。与这些观察结果一致的是，幼年猕猴的胸腺全切除与血浆皮质醇、促肾上腺皮质激素和β-内啡肽的减少有关。这些发现表明，青春期前灵长类胸腺含有促肾上腺皮质激素释放活性，这可能有助于发育中的免疫系统和垂体-肾上腺系统之间的生理免疫调节回路。
Endotoxin-free thymosin fraction 5 elevated corticotropin, β-endorphin, and cortisol in a dose- and time-dependent fashion when administered intravenously to prepubertal cynomolgus monkeys. Two synthetic component peptides of thymosin fraction 5 had no acute effects on pituitary function, suggesting that some other peptides in thymosin fraction 5 were responsible for its corticotropin-releasing activity. In agreement with these observations, total thymectomy of juvenile macaques was associated with decreases in plasma cortisol, corticotropin, and β-endorphin. These findings indicate that the prepubertal primate thymus contains corticotropin-releasing activity that may contribute to a physiological immunoregulatory circuit between the developing immunological and pituitary-adrenal systems.