Cross-sectional associations of tau protein biomarkers with semantic and episodic memory in older adults without dementia: A systematic review and meta-analysis.
Cross-sectional associations of tau protein biomarkers with semantic and episodic memory in older adults without dementia: A systematic review and meta-analysis.
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tau 蛋白生物标志物与无痴呆老年人语义和情景记忆的横断面关联：系统评价和荟萃分析。
DOI：
10.1016/j.arr.2021.101449
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发表时间：
2021
影响因子：
13.1
通讯作者：
Vonk,JetMJ
中科院分区：
文献类型：
--
作者：
Pelgrim,TeuntjeAD;Beran,Magdalena;Twait,EmmaL;Geerlings,MirjamI;Vonk,JetMJ
病理性tau蛋白被认为在阿尔茨海默病的临床前阶段的认知恶化中起作用。我们调查了tau蛋白负荷与无痴呆老年人情景记忆和语义记忆表现的横断面相关性。在MEDLINE（通过PubMed）、PsychINFO和Embase中进行系统检索，获得24项符合条件的研究进行荟萃分析。使用CSF、PET或组织病理学测量评估Tau负荷。所有研究都评估了tau蛋白与情景记忆的相关性：加权效应量为-0.46（95% CI [-0.73; -0.20]，p< .001），对于发作性综合评分，-0.19（[-0.36; -0.03]，p= 0.024），逻辑记忆为-0.05（[-0.14; 0.04]，p= 0.257）。14项研究评估了tau蛋白与语义记忆的关联：语义复合评分的加权效应量为-0.28（[-0.52; -0.04]，p= .023），语义流畅性为-0.06（[-0.16; 0.03]，p= .194），图片命名为0.06（[-0.06; 0.18]，p= .319）。我们的研究结果表明，tau蛋白负荷与未诊断为轻度认知障碍或明显痴呆的老年人的情景和语义记忆障碍有关，情景综合评分与tau蛋白负荷的相关性最强。未来的潜力在于开发更敏感的评分来检测这种微妙的认知障碍，这可能有助于早期识别阿尔茨海默病临床前阶段的个体，从而改善早期诊断和及时干预。
Pathological tau is suggested to play a role in cognitive deterioration in the preclinical phase of Alzheimer’s disease. We investigated cross-sectional associations of tau burden with episodic and semantic memory performance in older adults without dementia. A systematic search in MEDLINE (via PubMed), PsychINFO, and Embase resulted in 24 eligible studies for meta-analysis. Tau burden was assessed using CSF, PET, or histopathological measures. All studies evaluated associations of tau with episodic memory: weighted effect sizes were -0.46 (95 % CI [-0.73; -0.20],p< .001) for episodic composite scores, -0.19 ([-0.36; -0.03],p= .024) for delayed word list recall, and -0.05 ([-0.14; 0.04],p= .257) for logical memory. Fourteen studies evaluated associations of tau with semantic memory: weighted effect sizes were -0.28 ([-0.52; -0.04],p= .023) for semantic composite scores, -0.06 ([-0.16; 0.03],p= .194) for semantic fluency, and 0.06 ([-0.06; 0.18],p= .319) for picture naming. Our findings indicate that tau burden related to both episodic and semantic memory impairment in older individuals without a diagnosis of mild cognitive impairment or manifest dementia, with episodic composite scores showing the strongest association with tau burden. Future potential lies in developing more sensitive scores to detect this subtle cognitive impairment, which could contribute to early identification of individuals in the preclinical phase of Alzheimer’s disease, thereby improving early diagnosis and timely intervention.