A caspase homolog keeps CED-3 in check.
A caspase homolog keeps CED-3 in check.
复制标题
Caspase 同源物可控制 CED-3。
DOI：
10.1016/j.tibs.2008.11.003
复制
发表时间：
2009
影响因子：
13.8
通讯作者：
Duckett,ColinS
中科院分区：
文献类型：
--
作者：
Brady,GrahamF;Duckett,ColinS
细胞凋亡是细胞死亡的一种高度保守的形式，对于在生物体的整个生命周期中控制细胞数量至关重要。在秀丽隐杆线虫中，凋亡级联的最后一步是诱导死亡的蛋白酶CED-3的激活。到目前为止，还没有发现CED-3的直接负调节因子，因此维持适当生死平衡的机制尚不清楚。现在，一项新的研究确定CSP-3是C过程中CED-3的重要负调节因子。elegans发展。
Apoptosis is a highly conserved form of cell death that is essential for controlling cell numbers throughout the lifetime of an organism. InCaenorhabditis elegans, the final step in the apoptotic cascade is activation of the death-inducing protease CED-3. Until now, no direct negative regulators of CED-3 had been identified, so the mechanism for maintaining a proper life–death balance was unclear. Now, a new study identifies CSP-3 as an important negative regulator of CED-3 duringC. elegansdevelopment.