Troponin and S100 are associated with depression in healthy older adults
Troponin and S100 are associated with depression in healthy older adults
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DOI：
10.1080/13607860903046438
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发表时间：
2009-01-01
影响因子：
3.4
通讯作者：
Murray, Leigh
中科院分区：
文献类型：
--
作者：
Benitez, Andreana;Gunstad, John;Murray, Leigh
目标：抑郁症对老年人的功能有重大影响，并且通常先于认知能力下降或痴呆。目前的研究探讨了该人群中与神经认知结果相关的生物标志物与抑郁症之间的关联。方法：对 35 名无明显神经或精神病史的老年人进行空腹抽血和心理测试。分析了自我报告的抑郁症当前和病史测量结果以及脑源性神经营养因子、S100-β、淀粉样蛋白β和肌钙蛋白的测定结果。结果：发现肌钙蛋白水平与当前抑郁症呈负相关（r = -0.35，p = 0.03），而报告有抑郁症既往史的个体的 S100 水平显着高于未报告此病史的个体（t（33）= -2.08，p = 0.05）。结论：目前的研究表明神经认知生物标志物与抑郁症之间存在一定的关联，尽管这些关系的机制尚不清楚，需要进一步研究。
Objectives: Depression has a significant impact on the functioning of older adults and often precedes cognitive decline or dementia. The current study examines the association between biomarkers related to neurocognitive outcome and depression in this population. Method: Thirty-five older adults without significant neurological or psychiatric history underwent fasting blood draw and psychological testing. Self-reported measures of current and history of depression and assays for brain-derived neurotrophic factor, S100-beta, amyloid beta, and troponin were analyzed. Results: Troponin levels were found to be inversely related to current depression (r = -0.35, p = 0.03), while individuals who reported having a past history of depression had significantly higher levels of S100 than those who did not report this (t (33) = -2.08, p 0.05). Conclusion: The current study shows some support for the association of neurocognitive biomarkers to depression, though the mechanisms for these relationships are unclear and warrant further investigation.