Atrial natriuretic peptide clearance receptors in trout: effects of receptor inhibition in vivo.
Atrial natriuretic peptide clearance receptors in trout: effects of receptor inhibition in vivo.
复制标题
鳟鱼心房钠尿肽清除受体：体内受体抑制的影响。
DOI：
10.1002/jez.1402620315
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Olson,KR
中科院分区：
文献类型：
--
作者：
Duff,DW;Olson,KR
循环心钠素（ANP）通过专门的清除（C）受体的失活已在哺乳动物中进行了表征，但尚未在鱼类中进行过研究。在本研究中，在输注特异性C受体抑制剂SC-46542期间，测量了长期插管虹鳟鱼（Oncorhynchus mykiss）的动脉血压、尿流量和尿电解质。C受体抑制可降低血压和脉压，增加心率和尿流量，但不影响尿电解质浓度。这些反应与外源性ANP给药产生的反应一致，表明：（1）鳟鱼具有能够灭活ANP的C型受体，（2）ANP样分子在体内被鳟鱼持续释放和代谢。Phosphoramidon是一种中性内肽酶的抑制剂，它没有增强SC-46542的反应，表明C受体在这些鱼的ANP失活中占主导地位。© 1992 Wiley利斯公司
Inactivation of circulating atrial natriuretic peptides (ANP) by specialized clearance (C) receptors has been characterized in mammals but has not been examined in fish. In the present study arterial blood pressure, urine flow, and urine electrolytes were measured in chronically cannulated rainbow trout,Oncorhynchus mykiss, during infusion of the specific C receptor inhibitor, SC‐46542. C receptor inhibition decreased blood pressure and pulse pressure, increased heart rate and urine flow, but did not affect urinary electrolyte concentrations. These responses are consistent with those produced by exogenous ANP administration and indicate that: (1) trout possess C‐type receptors capable of ANP inactivation, and (2) ANP‐like molecules are continuously released and metabolized by trout in vivo. Phosphoramidon, an inhibitor of neutral endopeptidase, did not enhance the SC‐46542 response, indicating that C receptors predominate in ANP inactivation in these fish. © 1992 Wiley‐Liss, Inc.