Two populations of Ia-like molecules on a human B cell line.
Two populations of Ia-like molecules on a human B cell line.
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DOI：
10.4049/jimmunol.125.1.293
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发表时间：
1980-07
影响因子：
4.4
通讯作者：
L. Lampson;R. Levy
中科院分区：
文献类型：
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作者：
L. Lampson;R. Levy
证据是两个群体的IA样分子对人类B细胞系Raji。描述了两种单克隆抗体L203和L227。两者都识别B细胞抗原上的非多态性决定簇。两种免疫沉淀物均能从125 I标记的Raji提取物中沉淀34，000和28，000道尔顿的物质，但L227也能沉淀25，000道尔顿的物质。免疫耗竭实验证实抗体与两种不同的分子群体反应。
Evidence is presented for two populations of Ia-like molecules on the human B cell line Raji. Two monoclonal antibodies, L203 and L227, are described. Both recognize nonpolymorphic determinants on B cell antigens. Both immunoprecipitate 34,000- and 28,000-dalton material from 125I-labeled extracts of Raji, but L227 precipitates 25,000-dalton material as well. Immunodepletion experiments confirm that the antibodies react with two different populations of molecules.