Autonomously oscillating biochemical systems: parametric sensitivity of extrema and period
Autonomously oscillating biochemical systems: parametric sensitivity of extrema and period
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DOI：
10.1049/sb:20045005
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发表时间：
2004-06-01
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这项工作解决了自主振荡生化系统的灵敏度分析。从工程文献的结果的基础上，提出了一个一般性的分析，解决振荡轨迹的关键特征，即周期和局部最大值或最小值的物种，浓度和反应速率。敏感性不变量的讨论概括了稳态敏感性分析的结果。结果示出的昼夜节律振荡器的模型的应用程序。
This work addresses sensitivity analysis of autonomously oscillating biochemical systems. Building on results from the engineering literature, a general analysis is presented which addresses key features of oscillatory trajectories, namely the period and local maximum or minimum values of species, concentrations and reaction rates. A discussion of sensitivity invariants generalises results from steady-state sensitivity analysis to this context. The results are illustrated by the application to a model of a circadian oscillator.