Treatment of pathologic laughing and weeping with amitriptyline.
Treatment of pathologic laughing and weeping with amitriptyline.
复制标题
用阿米替林治疗病理性笑和哭。
DOI：
10.1056/nejm198506063122303
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Rudick,RA
中科院分区：
文献类型：
--
作者：
Schiffer,RB;Herndon,RM;Rudick,RA
双侧前脑疾病患者通常会出现病理性笑哭综合征。我们研究了低剂量阿米替林对 12 名多发性硬化症所致综合征患者的疗效。在一项比较阿米替林与安慰剂的双盲交叉研究中，8 名患者在阿米替林治疗后出现了显着的改善（P = 0.02）。阿米替林的平均剂量为每天 57.8 毫克，任何患者每天的剂量不超过 75 毫克。研究期间抑郁症的同步测量结果没有变化。我们得出结论，阿米替林可有效治疗这种情感表达障碍，并且这种作用与药物的抗抑郁作用不同。 （新英格兰医学杂志 1985 年；312：1480–2。）
Patients with bilateral forebrain disease may commonly manifest the syndrome of pathologic laughing and weeping. We investigated the efficacy of low-dose amitriptyline in 12 patients in whom this syndrome was a consequence of multiple sclerosis. In a double-blind crossover study comparing amitriptyline with placebo, eight patients experienced dramatic and significant improvement with amitriptyline (P = 0.02). The mean dose of amitriptyline was 57.8 mg per day and did not exceed 75 mg per day in any patient. Concurrent measurements of depression showed no change during the study.We conclude that amitriptyline is effective in the treatment of this disturbance of affective expression, and that this effect is distinct from the antidepressant effect of the medication. (N Engl J Med 1985; 312:1480–2.)