Strain difference of the adrenal cortex between A/J and SM/J mice, progenitors of SMXA recombinant inbred group.
Strain difference of the adrenal cortex between A/J and SM/J mice, progenitors of SMXA recombinant inbred group.
复制标题
SMXA重组近交系祖代A/J和SM/J小鼠肾上腺皮质应变差异。
作者：
S. Tanaka;M. Nishimura;J. Kitoh;A. Matsuzawa
重组近交系（RI）小鼠组可用于遗传分析的表型，这是由多个基因座调节。为了利用SM/J和A/J之间构建的SMXA RI群对肾上腺皮质形态发生进行遗传分析，我们对雌性肾上腺皮质进行了组织学比较，以检测A/J和SM/J之间的应变差异。SM/J的网状细胞明显厚于A/J，X区由A/J的空泡细胞和SM/J的非空泡细胞组成。结果表明，z。在A/J和SM/J之间，X区空泡化受3个不同位点控制。
The recombinant inbred (RI) mouse group is useful for genetic analysis of a phenotype which is regulated by multiple loci. The female adrenal cortex was compared histologically to detect the strain differences between A/J and SM/J for the purpose of genetic analysis of adrenocortical morphogenesis using the SMXA RI group constructed between A/J and SM/J. Clear morphological differences were found in the zona reticularis and X zone in addition to the significantly small body and adrenal weights in SM/J. The z. reticularis was markedly thicker in SM/J than in A/J and the X zone was constituted of vacuolated cells in A/J and non-vacuolated cells in SM/J. The genetic control of these morphological traits was analyzed using SMXA RI strains. The results suggest that the thickness of the z. reticularis may be controlled by single locus and that vacuolation of the X zone by 3 different loci between A/J and SM/J.