OPPOSITE-STRAND RNAS FROM THE 5' FLANKING REGION OF THE MOUSE DIHYDROFOLATE-REDUCTASE GENE
OPPOSITE-STRAND RNAS FROM THE 5' FLANKING REGION OF THE MOUSE DIHYDROFOLATE-REDUCTASE GENE
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DOI：
10.1073/pnas.82.12.3978
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
SCHIMKE, RT
中科院分区：
文献类型：
--
作者：
FARNHAM, PJ;ABRAMS, JM;SCHIMKE, RT
在编码二氢叶酸还原酶（EC 1.5.1.3）的小鼠基因的5”侧翼区域发现了一个与二氢叶酸还原酶转录方向相反的转录单元。这些对链RNA有180-240个核苷酸长，在它们的5'端长度不同。它们在核RNA中含量丰富，不会被聚腺苷化。二氢叶酸还原酶基因的启动子区域可能以双向方式产生这些RNA和二氢叶酸还原酶mRNA。
A transcription unit was characterized in the 5'' flanking region of the mouse gene encoding dihydrofolate reductase (EC 1.5.1.3) that is oriented in the opposite direction to that of dihydrofolate reductase transcription. These opposite-strand RNA are 180-240 nucleotides long, differing in length at their 5'' ends. They are abundant in nuclear RNA and are not polyadenylylated. The promoter region of the dihydrofolate reductase gene may function in a bidirectional manner to produce both these RNA and dihydrofolate reductase mRNA.