Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia
Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia
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DOI：
10.1111/bjh.12496
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发表时间：
2013-11-01
影响因子：
6.5
通讯作者：
Clark, Chris A.
中科院分区：
文献类型：
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作者：
Kawadler, Jamie M.;Clayden, Jonathan D.;Clark, Chris A.
镰状细胞贫血（SCA）与无症状性脑梗死（SCI）有关，累及白色和皮质灰质，但皮质下体积的数据很少。我们分析了26例SCA患者和20例对照组的回顾性磁共振成像（MRI）数据，比较了三组之间的平均皮质下体积：对照组，SCA伴SCI（n=13）和SCA无明显异常（n=13）。海马、杏仁核、苍白球、尾状核、壳核、丘脑和小脑的体积差异。这是第一个研究，以证明皮层下体积变化的SCA，最严重的体积赤字发生在儿童脊髓损伤的MRI上看到。
Sickle cell anaemia (SCA) is associated with silent cerebral infarction (SCI), affecting white and cortical grey matter, but there are few data on subcortical volumes. We analysed retrospective magnetic resonance imaging (MRI) data in 26 SCA patients and 20 controls, comparing mean subcortical volumes between three groups: controls, SCA with SCI (n=13) and SCA without visible abnormality (n=13). Specific volumetric differences were found in the hippocampus, amygdala, pallidum, caudate, putamen, thalamus, and cerebellum. This is the first study to demonstrate subcortical volume change in SCA, with the most severe volumetric deficits occurring in children with SCI seen on MRI.