Variability in diagnostic criteria for chronic fatigue syndrome may result in substantial differences in patterns of symptoms and disability
Variability in diagnostic criteria for chronic fatigue syndrome may result in substantial differences in patterns of symptoms and disability
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DOI：
10.1177/0163278702250071
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发表时间：
2003-03-01
影响因子：
2.9
通讯作者：
Taylor, RR
中科院分区：
文献类型：
--
作者：
Jason, LA;Helgerson, J;Taylor, RR
慢性疲劳综合症 (CFS) 是一种涉及严重、长时间疲劳以及神经、免疫和内分泌系统病理学的疾病。由于 CFS 的发病机制尚未确定，病例定义依赖于临床观察对体征和症状进行分类以进行诊断。目前的调查研究了福田及其同事定义的慢性疲劳综合症与肌痛性脑脊髓炎 (ME) 规定的一组标准之间的差异。相关指标包括精神共病、症状频率、症状严重程度和功能障碍。 ME 和福田等人。 (1994) 将 CFS 标准与因精神原因而患有慢性疲劳的组进行比较。显着差异主要发生在神经系统、神经精神、疲劳/虚弱和风湿病症状方面。这些发现表明，综合使用不同定义来选择研究人群的这种疾病的研究结果可能是不合适的。
Chronic fatigue syndrome (CFS) is an illness that involves severe, prolonged exhaustion as well as neurologic, immunologic, and endocrine system pathology. Because the pathogenesis of CFS has yet to be determined, case definitions have relied on clinical observation in classifying signs and symptoms for diagnosis. The current investigation examined differences between CFS as defined by Fukuda and colleagues and a set of criteria that has been stipulated for myalgic encephalomyelitis (ME). Dependent measures included psychiatric comorbidity, symptom frequency, symptom severity, and functional impairment. The ME and Fukuda et al. (1994) CFS criteria were compared with a group having chronic fatigue due to psychiatric reasons. Significant differences occurred primarily with neurologic, neuropsychiatric, fatigue/weakness, and rheumatological symptoms. These findings suggest that it might be inappropriate to synthesize results from studies of this illness that use different definitions to select study populations.