Relationship between Sedative Antihistamines and the Duration of Febrile Seizures
Relationship between Sedative Antihistamines and the Duration of Febrile Seizures
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DOI：
10.1055/s-0040-1701226
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发表时间：
2020-04-01
期刊：
影响因子：
1.4
通讯作者：
Kawashima, Hisashi
中科院分区：
文献类型：
--
作者：
Daida, Atsuro;Yamanaka, Gaku;Kawashima, Hisashi
一些研究表明，镇静抗组胺药延长热性惊厥持续时间。尽管集体证据仍然混杂，但日本儿童神经病学学会在2015年发布了指南，禁止在热性惊厥患者中使用镇静抗组胺药。为了解决以往研究的局限性，我们进行了一项横断面研究，以评估热性惊厥持续时间和镇静抗组胺药的使用之间的关系。数据收集自2013年8月至2016年2月期间因热性惊厥就诊于圣卢克国际医院的患者。根据处方药物将患者分组：镇静抗组胺药、非镇静抗组胺药和无抗组胺药。癫痫发作持续时间是主要结果，并采用多变量分析进行了检查。在纳入的426例患者中，24例患者接受了镇静抗组胺药治疗。所有三组的中位癫痫发作持续时间约为3分钟。在双变量（p = 0.422）或多变量分析（p = 0.544）中无统计学差异。我们的研究结果不支持镇静抗组胺药的使用和热性惊厥持续时间延长之间的关系。这些结果表明，在适当的情况下，对于既往有热性惊厥病史的患者，可以考虑使用抗组胺药。
Some studies have shown that sedative antihistamines prolong febrile seizure duration. Although the collective evidence is still mixed, the Japanese Society of Child Neurology released guidelines in 2015 that contraindicated the use of sedative antihistamines in patients with febrile seizure. Focused on addressing limitations of previous studies, we conducted a cross-sectional study to evaluate the relationship between febrile seizure duration and the use of sedative antihistamines. Data were collected from patients who visited St. Luke's International Hospital due to febrile seizure between August 2013 and February 2016. Patients were divided into groups based on their prescribed medications: sedative antihistamine, nonsedative antihistamine, and no antihistamine. Seizure duration was the primary outcome and was examined using multivariate analyses. Of the 426 patients included, sedative antihistamines were administered to 24 patients. The median seizure duration was approximately 3 minutes in all three groups. There was no statistical difference in the bivariate ( p = 0.422) or multivariate analyses ( p = 0.544). Our results do not support the relationship between sedative antihistamine use and prolonged duration of febrile seizure. These results suggest that the use of antihistamines may be considered for patients with past history of febrile seizure, when appropriate.