Reactivations of emotional memory in the hippocampus-amygdala system during sleep
Reactivations of emotional memory in the hippocampus-amygdala system during sleep
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DOI：
10.1038/nn.4637
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发表时间：
2017-11-01
影响因子：
25
通讯作者：
Buzsaki, Gyorgy
中科院分区：
文献类型：
--
作者：
Girardeau, Gabrielle;Inema, Ingrid;Buzsaki, Gyorgy
情境依赖性情绪记忆的巩固需要海马和基底外侧杏仁核（BLA）之间的交流，但这一过程的机制尚不清楚。我们记录了当大鼠在线性轨迹上学习厌恶的空气膨胀的位置时，以及在训练前后的睡眠期间，海马体和BLA中的神经元集合。我们发现在训练后的非快速眼动睡眠期间，海马体和BLA之间有协调的再激活。这些再激活在海马尖波波纹（SPW-Rs）期间达到顶峰，并涉及海马尖波波纹期间正调节的BLA细胞亚群。值得注意的是，与“安全”方向相比，代表跑步方向的海马体- bla相关模式的再激活更强。这些发现表明，情境情绪记忆的巩固发生在海马体-杏仁核回路的涟漪再激活过程中。
The consolidation of context-dependent emotional memory requires communication between the hippocampus and the basolateral amygdala (BLA), but the mechanisms of this process are unknown. We recorded neuronal ensembles in the hippocampus and BLA while rats learned the location of an aversive air puff on a linear track, as well as during sleep before and after training. We found coordinated reactivations between the hippocampus and the BLA during non-REM sleep following training. These reactivations peaked during hippocampal sharp wave-ripples (SPW-Rs) and involved a subgroup of BLA cells positively modulated during hippocampal SPW-Rs. Notably, reactivation was stronger for the hippocampus-BLA correlation patterns representing the run direction that involved the air puff than for the 'safe' direction. These findings suggest that consolidation of contextual emotional memory occurs during ripple-reactivation of hippocampus-amygdala circuits.