Genotype Distribution and Molecular Epidemiology of Hepatitis C Virus in Guangzhou, China: Predominance of Genotype 1b and Increasing Incidence of Genotype 6a
Genotype Distribution and Molecular Epidemiology of Hepatitis C Virus in Guangzhou, China: Predominance of Genotype 1b and Increasing Incidence of Genotype 6a
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中国广州丙型肝炎病毒基因型分布和分子流行病学：基因型1b占优势，基因型6a发病率上升
DOI：
10.1159/000481561
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发表时间：
2017-01-01
影响因子：
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通讯作者：
Zhou, Yuanping
中科院分区：
文献类型：
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作者：
Yuan, Guosheng;Liu, Junwei;Zhou, Yuanping
背景/目的：丙型肝炎病毒（HCV）基因型的地理分布不同，可能与传播方式有关。中国广州HCV感染的分子流行病学知之甚少。方法：对南方医科大学南方医院登记的561例慢性HCV感染患者进行横断面调查。所有居民接受问卷调查，了解其个人状况和商业献血史。结果：最终共纳入463例慢性丙型肝炎（CHC）患者。在463份样本中，426份具有部分核心- e1序列，可分为1b （n=263, 61.7%）、6a （n=86, 20.2%）、2a （n=26, 6.1%）、3b （n=26, 6.1%）、3a （n=22, 5.2%）、6u （n=2, 0.5%）和4a (n=1, 0.2%) 7个亚型。基因型相关危险因素分析显示，献血和输血与1b和2a亚型密切相关，而基因型3b和6a在静脉吸毒者中更为常见。结论：系统地理分析表明广州市HCV基因型分布复杂。有趣的是，6a已成为广州的地方性流行病，可能是6a向其他省份传播的第二个源头地区。
Background/Aims: Distribution of Hepatitis C virus (HCV) genotypes vary geographically and may associate with the mode of transmission. Little is known about the molecular epidemiology of HCV infection in Guangzhou, China. Methods: A cross-sectional survey included 561 subjects with chronic HCV infection registered at Nanfang Hospital, Southern Medical University, was performed. All residents were invited for a questionnaire interview to collect information about their personal status and commercial blood donation history. Results: A total of 463 chronic hepatitis C (CHC) patients were finally enrolled. Among the 463 samples, 426 were characterized by partial core-E1 sequences and classified into 7 subtypes: 1b (n=263, 61.7%), 6a (n=86, 20.2%), 2a (n=26, 6.1%), 3b (n=26, 6.1%), 3a (n=22, 5.2%), 6u (n=2, 0.5%), and 4a (n=1, 0.2%). Analysis of genotype-associated risk factors revealed that blood donation and transfusion were strongly associated with subtypes 1b and 2a, while genotype 3b and 6a were more frequent in intravenous drug users. Conclusions: Phylogeographic analyses demonstrated that the distribution of HCV genotypes in Guangzhou is complex. Interestingly, 6a has become a local endemic in Guangzhou and may be the second source region to disseminate 6a to other provinces.