Oxygen Starvation Unmasks a Killer.
Oxygen Starvation Unmasks a Killer.
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缺氧揭露杀手。
DOI：
10.1016/j.chembiol.2018.10.028
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发表时间：
2018
影响因子：
8.6
通讯作者：
Hergenrother,PaulJ
中科院分区：
文献类型：
--
作者：
Svec,RileyL;Hergenrother,PaulJ
In this issue ofCell Chemical Biology, Jacobsen et al. (2018) investigate the hypoxia selectivity of two cyclolipodepsipeptide natural products bearing a 4-amido-2,4-pentadienoate warhead. A switch in the cell death pathway under hypoxic conditions is observed, suggesting these electrophilic natural products have potential as a prodrug-free approach for treating hypoxic tumors.
