Metal-Mediated Nanoscale Cerium Oxide Inactivates Human Coronavirus and Rhinovirus by Surface Disruption
Metal-Mediated Nanoscale Cerium Oxide Inactivates Human Coronavirus and Rhinovirus by Surface Disruption
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DOI：
10.1021/acsnano.1c04142
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发表时间：
2021-08-26
期刊：
影响因子：
17.1
通讯作者：
Seal, Sudipta
中科院分区：
文献类型：
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作者：
Neal, Craig J.;Fox, Candace R.;Seal, Sudipta
总体而言，新冠病毒大流行引起了全球对新兴病毒威胁和抗病毒疗法的关注。特别是呼吸道病毒的高传播性和传染性已引起公众的关注，以及对高效抗病毒和消毒材料/产品的需求。本研究开发了两种不同的银改性氧化还原纳米级氧化铈配方（AgCNP1 和 AgCNP2）。该配方对测试的 OC43 冠状病毒和 RV14 鼻病毒病原体表现出特定的抗病毒活性，材料表征表明二氧化铈颗粒上的银纳米相具有化学稳定性特征，并且 Ce3+/Ce4+ 氧化还原态比率存在显着差异（AgCNP1 和 2 分别为 25.8% 和 53.7% Ce3+）。原位电化学研究进一步强调了制剂特异性病毒灭活的差异，并提出了具体的作用模式。总而言之，这项研究的结果支持 AgCNP 制剂作为高稳定性、高效材料用于对抗临床相关病毒种类的用途。
The COVID19 pandemic has brought global attention to the threat of emerging viruses and to antiviral therapies, in general. In particular, the high transmissibility and infectivity of respiratory viruses have been brought to the general public's attention, along with the need for highly effective antiviral and disinfectant materials/products. This study has developed two distinct silver-modified formulations of redoxactive nanoscale cerium oxide (AgCNP1 and AgCNP2). The formulations show specific antiviral activities toward tested OC43 coronavirus and RV14 rhinovirus pathogens, with materials characterization demonstrating a chemically stable character for silver nanophases on ceria particles and significant differences in Ce3+/Ce4+ redox state ratio (25.8 and 53.7% Ce3+ for AgCNP1 & 2, respectively). In situ electrochemical studies further highlight differences in formulation-specific viral inactivation and suggest specific modes of action. Altogether, the results from this study support the utility of AgCNP formulations as high stability, high efficacy materials for use against clinically relevant virus species.