Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study.
Maternal depression attenuates newborn vitamin D concentrations in winter-spring: a prospective population-based study.
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母亲抑郁会降低冬春季节新生儿维生素 D 浓度：一项基于人群的前瞻性研究
DOI：
10.1038/s41598-017-01778-1
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发表时间：
2017-05-08
影响因子：
4.6
通讯作者：
Zhu P
中科院分区：
文献类型：
--
作者：
Zhou QF;Zhang MX;Tong SL;Tao RX;Hao JH;Huang K;Tao FB;Zhu P
我们的目的是调查是否有母亲抑郁症（MD）的新生儿比非MD（NMD）母亲的新生儿有较低的维生素D水平，并确定这种关联的潜在机制。对1491对母婴进行了孕晚期母亲抑郁症状和脐血25羟维生素D（25（OH）D）浓度的测定。前瞻性地收集关于产妇社会人口学特征、健康状况、生活方式和出生结局的数据。对于冬春季节出生的婴儿，与NMD母亲的婴儿相比，MD母亲的婴儿25（OH）D浓度显著降低（校正后β = −3.51 nmol/L; 95% CI：−6.19，−0.84;P= 0.010），出生体重显著降低（3267 ± 470 g vs 3348 ± 598 g，F = 4.64，P = 0.031）。母亲抑郁评分与冬春季出生婴儿的25（OH）D浓度之间存在显著的反线性关系（调整后的β = −0.158; 95%CI：−0.259，−0.057）。在冬春季出生的婴儿中，也观察到母亲抑郁评分与25（OH）D的母胎比之间存在显著的反向线性关系（校正后的β = −0.005; 95% CI：−0.008，−0.003）。MD似乎显着减弱维生素D浓度和出生体重的婴儿出生在冬春季。25（OH）D的母胎比降低可能参与了这一生物学途径。
We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (25(OH)D) were measured in 1491 mother-infant pairs. Data on maternal sociodemographic characteristics, health status, lifestyle and birth outcomes were prospectively collected. For infants born in winter-spring, the infants of MD mothers had significantly reduced concentrations of 25(OH) D (adjusted β = −3.51 nmol/L; 95% CI: −6.19, −0.84;P= 0.010) and lower birth weight (3267 ± 470 g vs 3348 ± 598 g, F = 4.64,P= 0.031), compared with the infants of NMD mothers. A significant, inverse linear relationship was noted between maternal depression scores and the concentration of 25(OH)D for infants born in winter-spring (adjusted β = −0.158; 95% CI: −0.259, −0.057). The significant, inverse linear relationship between maternal depression scores and fetomaternal ratios of 25(OH) D was also observed among the infants born in winter-spring (adjusted β = −0.005; 95% CI: −0.008, −0.003). MD appears to significantly attenuate the vitamin D concentrations and birth weight of infants born in winter-spring. A decreased fetomaternal ratio of 25(OH)D might be involved in this biological pathway.