Germ cell tumors: Insights from the Drosophila ovary and the mouse testis.
Germ cell tumors: Insights from the Drosophila ovary and the mouse testis.
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DOI：
10.1002/mrd.22779
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发表时间：
2017-03
影响因子：
2.5
通讯作者：
Heaney JD
中科院分区：
文献类型：
--
作者：
Salz HK;Dawson EP;Heaney JD
年轻成人卵巢和睾丸生殖细胞肿瘤被认为是由生殖细胞发育缺陷引起的，但其恶性转化的分子机制尚不清楚。在这篇综述中，我们关注果蝇卵巢和小鼠睾丸中生殖细胞肿瘤形成的生物学，证据支持常见的潜在机制，如阻断分化途径的启动，谱系进展受损和性别身份不稳定。然后，我们讨论这些概念如何告知我们对人类疾病的理解。
Ovarian and testicular germ cell tumors of young adults are thought to arise from defects in germ cell development, but the molecular mechanisms underlying malignant transformation are poorly understood. In this review, we focus on the biology of germ cell tumor formation in the Drosophila ovary and the mouse testis, for which the evidence supports common underlying mechanisms such as blocking initiation into the differentiation pathway, impaired lineage progression, and sexual identity instability. We then discuss how these concepts inform our understanding of the disease in humans.