Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenal.
Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenal.
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朝着从阿森纳链霉菌发现抗生素和药物发现的新重点。
DOI：
10.3389/fmicb.2015.00461
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发表时间：
2015
影响因子：
5.2
通讯作者：
Rodríguez H
中科院分区：
文献类型：
--
作者：
Antoraz S;Santamaría RI;Díaz M;Sanz D;Rodríguez H
耐抗生素病原体的出现正在改变科学家寻找新型抗生素化合物的方式。这种对抗日益流行的多重耐药菌株的竞赛，使得有必要加快寻找具有抗生素活性的新化合物，并增加已知抗生素的生产。在这里，我们回顾了各种新的科学方法，旨在提高链霉菌的抗生素生产。这些包括：(i)阐明触发抗生素生物合成途径的信号，以改善培养基；（ii）细菌激素研究，旨在重现导致抗生素爆发的种内和种间通信；（iii）共同培养，模拟自然界中的竞争-合作情景；（iv）最近在原地寻找可能应用于链霉菌自然栖息地的抗生素。这些新的研究策略与新的分析和分子技术相结合，应该在新化合物的紧迫性比以往任何时候都高的时候加速发现过程。
Emergence of antibiotic resistant pathogens is changing the way scientists look for new antibiotic compounds. This race against the increased prevalence of multi-resistant strains makes it necessary to expedite the search for new compounds with antibiotic activity and to increase the production of the known. Here, we review a variety of new scientific approaches aiming to enhance antibiotic production in Streptomyces. These include: (i) elucidation of the signals that trigger the antibiotic biosynthetic pathways to improve culture media, (ii) bacterial hormone studies aiming to reproduce intra and interspecific communications resulting in antibiotic burst, (iii) co-cultures to mimic competition-collaboration scenarios in nature, and (iv) the very recent in situ search for antibiotics that might be applied in Streptomyces natural habitats. These new research strategies combined with new analytical and molecular techniques should accelerate the discovery process when the urgency for new compounds is higher than ever.