Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship.

Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship.
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DOI:
10.1080/13554794.2011.654227
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发表时间:
2013-04
期刊:
影响因子:
0.8
通讯作者:
Kramer JH
Kramer JH
中科院分区:
医学4区
文献类型:
--
作者:
Bettcher BM;Kramer JH

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在过去的十年中,一种可能改变或加剧老年人神经退行性疾病表现的免疫机制受到了相当大的关注,最近的研究表明促炎标志物与神经退行性疾病之间存在密切联系。以下综述的总体目标是综合最近的研究,这些研究支持炎症与神经退行性疾病的临床特征之间可能存在的关系,包括发展风险、认知和临床相关性以及特定疾病的进展。特别强调的是提供一个时间的背景下,炎症和神经退行性变之间的关联。
A proposed immune mechanism that potentially modifies or exacerbates neurodegenerative disease presentation in older adults has received considerable attention in the past decade, with recent studies demonstrating a strong link between pro-inflammatory markers and neurodegeneration. The overarching aim of the following review is to synthesize recent research that supports a possible relationship between inflammation and clinical features of neurodegenerative diseases, including risk of development, cognitive and clinical correlates, and progression of the specified diseases. Specific emphasis is placed on providing a temporal context for the association between inflammation and neurodegeneration.
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