Color Processing in the Early Visual System of Drosophila
Color Processing in the Early Visual System of Drosophila
复制标题
DOI：
10.1016/j.cell.2017.12.018
复制
发表时间：
2018-01-11
期刊：
影响因子：
64.5
通讯作者：
Reiff, Dierk F.
中科院分区：
文献类型：
--
作者：
Schnaitmann, Christopher;Haikala, Vaeinoe;Reiff, Dierk F.
色觉通过比较具有不同视觉色素的光感受器的信号来提取光谱信息。这种比较是由颜色对立的神经元编码的，这些神经元在一个波长上兴奋，在另一个波长上抑制。在这里，我们通过结合双光子钙成像和视觉回路的遗传解剖来研究果蝇视觉系统中颜色对抗处理的回路实现。我们报道了UVShort/Blue和UVlong/Green在R7/R8内部光感受器“淡”和“黄”小眼中分别进行了颜色对抗加工。同一类型小眼的R7和R8光感受器通过组胺受体HisCl1直接相互抑制，并接受额外的反馈抑制，这需要第二组胺受体Ort。在第一个视觉突触上进行的颜色对抗处理代表了果蝇和脊椎动物之间一个意想不到的共同点；然而，分子和细胞实现上的差异表明，相同的原理是独立进化的。
Color vision extracts spectral information by comparing signals from photoreceptors with different visual pigments. Such comparisons are encoded by color-opponent neurons that are excited at one wavelength and inhibited at another. Here, we examine the circuit implementation of color-opponent processing in the Drosophila visual system by combining two-photon calcium imaging with genetic dissection of visual circuits. We report that coloropponent processing of UVshort/blue and UVlong/green is already implemented in R7/R8 inner photoreceptor terminals of "pale'' and "yellow'' ommatidia, respectively. R7 and R8 photoreceptors of the same type of ommatidia mutually inhibit each other directly via HisCl1 histamine receptors and receive additional feedback inhibition that requires the second histamine receptor Ort. Color-opponent processing at the first visual synapse represents an unexpected commonality between Drosophila and vertebrates; however, the differences in the molecular and cellular implementation suggest that the same principles evolved independently.