Viral load of HPV 16/18 in esophageal squamous cell carcinoma in three ethnic groups living in Xinjiang Autonomous Region, China
Viral load of HPV 16/18 in esophageal squamous cell carcinoma in three ethnic groups living in Xinjiang Autonomous Region, China
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中国新疆自治区三个民族食管鳞癌中HPV 16/18病毒载量
DOI：
10.1007/s11033-012-2263-y
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Sheyhidin I
中科院分区：
文献类型：
--
作者：
Zheng S;Li X;Lu X;Sheyhidin I
To investigate the viral load of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) patients from three ethnic groups in Xinjiang. Using Gp5+/Gp6+ consensus primers, the prevalence of HPV DNA was examined in 253 paraffin-embedded ESCC samples. The presence and viral load of HPV 16 and HPV 18 were detected in Kazakhs, Uygurs and Hans using type-specific primers by quantitative real-time PCR (qRT-PCR). Among the 253 ESCC samples, 52 cases were positive for HPV DNA, all the 52 positive cases displayed HPV 16 infection, and six of the 52 cases were co-infected by HPV 16 and 18. HPV 16-positive rate and viral load were higher in lesions, and was inversely correlated with differentiation grades. However, there was no statistic significance among different differentiation grades. Also, there were no significant difference between detection rates of HPV types, viral load and age, gender, ethnic group, and lymph node metastasis. HPV 16 and HPV 18 genotypes could simultaneously be detected in ESCC specimens in three main ethnic groups in Xinjiang. The viral load of HPV 16 is higher in the ESCC lesions, and is inversely correlated with the differentiation grades. These observations reinforce the suggestion that HPV infection may involved in ESCC carcinogenesis; however, high prevalence or viral load of HPV infection does not seem to be related with high incidence of ESCC in Kazakhs, which may be the one element among the multiple risk factors contributing to ESCC.
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影响因子：
3.6
作者：
R. Ralhan;R. Mathew;S. Arora;R. Bahl;N. Shukla;M. Mathur
通讯作者：
R. Ralhan;R. Mathew;S. Arora;R. Bahl;N. Shukla;M. Mathur
影响因子：
3.5
作者：
I. Zehbe;Eva Rylander;K. Edlund;Göran Wadell;Erik Wilander
通讯作者：
I. Zehbe;Eva Rylander;K. Edlund;Göran Wadell;Erik Wilander
DOI：
10.1016/j.ejso.2007.11.007
发表时间：
2008-07
期刊：
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
影响因子：
--
作者：
Xiaomei Lu;S. Monnier-Benoit;L. Mo;S. Y. Xu;J. Prétet;Z. Liu;D. Vuitton;C. Mougin
通讯作者：
Xiaomei Lu;S. Monnier-Benoit;L. Mo;S. Y. Xu;J. Prétet;Z. Liu;D. Vuitton;C. Mougin
影响因子：
3.3
作者：
CHEN, BF;YIN, H;DHURANDHAR, N
通讯作者：
DHURANDHAR, N
影响因子：
6.4
作者：
Si, HX;Tsao, SW;Cheung, ALM
通讯作者：
Cheung, ALM