PREVENTION OF POSTOPERATIVE ADHESIONS BY TISSUE-TYPE PLASMINOGEN-ACTIVATOR (T-PA) IN THE RABBIT
PREVENTION OF POSTOPERATIVE ADHESIONS BY TISSUE-TYPE PLASMINOGEN-ACTIVATOR (T-PA) IN THE RABBIT
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DOI：
10.1016/0028-2243(90)90037-2
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发表时间：
1990-12-01
影响因子：
2.6
通讯作者：
ROLLAND, R
中科院分区：
文献类型：
--
作者：
DORR, PJ;VEMER, HM;ROLLAND, R
腹膜的纤溶系统在粘连的发病机制中是重要的。纤溶酶原激活剂活性被血清型损伤抑制，引起局部缺血。缺血性腹膜引起腹膜粘连。当局部纤溶活性受损时，可能会出现纤维蛋白持续存在和粘连组织化。通过干燥子宫角的浆膜并通过腹腔内引入少量血液来在兔中产生腹膜粘连。在一组家兔中，组织型纤溶酶原激活剂（t-PA）在手术结束时腹腔注射：另一组作为对照组。48只家兔分别于术后3 h、1、3、7 d处死动物，观察粘连情况。对照组的所有动物均出现粘连。t-PA组动物的粘连比对照组动物少。
The fibrinolytic system of the peritoneum is important in the pathogenesis of adhesions. Plasminogen activator activity is depressed by serosal types of injury, which cause ischemia. Ischemic peritoneum induces fibrinous adhesions. When local fibrinolytic activity is impaired, persistence of fibrin and organisation of the fibrinous adhesions may occur. Peritoneal adhesion in rabbits were created by drying the serosa of the uterine horns and by introducing a small amount of blood intraperitoneally. In one group of rabbits tissue-type plasminogen activator (t-PA) was given intraperitoneally at the end of the operation: another group served as controls. 48 rabbits were operated on. The animals were killed 3 h, 1, 3 and 7 days postoperatively for evaluation of adhesions. All animals of the control group had adhesions. The animals of the t-PA group had less adhesions than the animals of the control group.