Corrosion resistance of bioinspired DNA-induced Ca-P coating on biodegradable magnesium alloy
Corrosion resistance of bioinspired DNA-induced Ca-P coating on biodegradable magnesium alloy
复制标题
可生物降解镁合金上仿生 DNA 诱导 Ca-P 涂层的耐腐蚀性能
DOI：
10.1016/j.jma.2019.01.004
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发表时间：
2019
影响因子：
17.6
通讯作者：
Cui Lan Yue
中科院分区：
文献类型：
--
作者：
Liu Ping;Wang Jia Min;Yu Xiao Tong;Chen Xiao Bo;Li Shuo Qi;Chen Dong Chu;Guan Shao Kang;Zenga Rong Chang;Cui Lan Yue
生物涂层具有降低腐蚀率和增强结合强度的特点，是未来可降解镁(Mg)基植入物临床应用的核心。有机和无机化合物的混合为在生物医用镁合金表面制备可生物降解、生物相容和致密的涂层提供了一种策略。在此基础上，比较了添加DNA前后AZ31合金表面水热沉积钙磷涂层的耐蚀性和结合强度。采用扫描电子显微镜、能谱仪、傅立叶变换红外光谱仪和X射线衍射仪对腐蚀前后涂层的形貌、化学成分和晶体结构进行了分析。通过动电位极化曲线、电化学阻抗谱(EIS)和在Hank‘s溶液中的析氢试验来评价其耐蚀性。结果表明，涂层主要由磷酸三钙(TCP)、无水磷酸氢钙(DCPA)和缺钙羟基磷灰石(CDHA)组成。DNA的存在导致了钙磷涂层的形成，提高了耐腐蚀性和结合强度。此外，还对DNA诱导钙磷涂层的形成机理进行了探讨。DNA诱导的钙磷涂层在控制可生物降解镁合金的腐蚀速率方面具有广阔的应用前景。
Bioinspired coatings with decreased corrosion rate and enhanced bond strength are at the core of future clinic applications on degradable magnesium (Mg)-based implants. The hybrid of organic and inorganic compounds offers a strategy to fabricate biodegradable, biocompatible and compact coatings on biomedical Mg alloys. Hereby, a comparison with and without DNA addition was made on the corrosion resistance and adhesion strength of Ca–P coatings fabricated on AZ31 alloy via hydrothermal deposition. The morphology, chemical composition, and crystallographic structure of the coatings were investigated by means of SEM, EDS and FTIR as well as XRD before and after corrosion tests. Corrosion resistance was evaluated via potentiodynamic polarization curves, electrochemical impedance spectroscopy (EIS) and hydrogen evolution tests in Hank's solution. Results show that the coatings are mainly characterized by tricalcium phosphate (TCP), dicalcium phosphate anhydrous (DCPA) and calcium-deficient hydroxyapatite (CDHA). The presence of DNA leads to the formation of Ca–P coating with improved corrosion resistance and adhesion strength. Additionally, the formation mechanism for DNA-induced Ca–P coating is proposed. The DNA-induced Ca–P coating exhibits a promising future for controlling the corrosion rate of biodegradable Mg alloys.