Hypoxia, angiogenesis and cancer therapy To breathe or not to breathe?
Hypoxia, angiogenesis and cancer therapy To breathe or not to breathe?
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DOI：
10.4161/cc.8.20.9741
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发表时间：
2009-10-15
期刊：
影响因子：
4.3
通讯作者：
Michieli, Paolo
中科院分区：
文献类型：
--
作者：
Michieli, Paolo
当不断扩大的肿瘤征服宿主体内的空间时，它需要增加氧气供应。这种需求很少能与肿瘤血管相匹配，因为新血管生成会产生结构异常和功能受损的脉管系统。由于这种不平衡，肿瘤进展总是与癌细胞缺氧有关。氧合不足似乎对癌症生物学产生相反的影响：一方面，它限制肿瘤细胞分裂；另一方面，它限制肿瘤细胞的分裂。另一方面，它选择更多的恶性细胞，并诱导一系列维持和促进肿瘤侵袭的细胞适应。在设计治疗策略时，我们应该如何解决这种二分法？我们应该切断氧气供应，从而阻止肿瘤扩张，还是应该让肿瘤呼吸，以防止其恶性转化？
As an expanding tumor conquers space within the host, it calls out for an increased oxygen supply. This demand is rarely matched by tumor blood vessels because neo-angiogenesis generates a structurally aberrant and functionally impaired vasculature. As a result of this unbalance, tumor progression is invariably associated with cancer cell hypoxia. Insufficient oxygenation appears to have opposing effects on cancer biology: on one hand, it limits tumor cell division; on the other, it selects for more malignant cells and it induces a series of cellular adaptations that sustain and foster tumor invasion. When designing a therapeutic strategy, how should we resolve this dichotomy? Should we cut oxygen supply, thereby halting neoplastic expansion, or should we let the tumor breathe, in order to prevent its malignant conversion?