The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer.
The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer.
复制标题
癌症相关成纤维细胞对胰腺癌主要特征的影响
作者：
Sun Q;Zhang B;Hu Q;Qin Y;Xu W;Liu W;Yu X;Xu J
胰腺导管腺癌(PDAC)是最具挑战性的致命性肿瘤之一，预后差。除了癌细胞，由一系列驻留和招募的细胞以及细胞外基质创造的肿瘤微环境也有助于获得癌症的特征。其中，肿瘤相关成纤维细胞(CAF)是肿瘤微环境的重要组成部分。CAF起源于体内成纤维细胞和胰腺星状细胞的激活、骨髓间充质干细胞的分化和上皮向间充质的转化。CAF通过多种细胞因子获得激活的表型，促进肿瘤的增殖和生长，加速侵袭和转移，诱导血管生成，促进炎症和免疫破坏，调节肿瘤代谢，诱导化疗耐药，这些因素有助于获得PDAC的主要特征。因此，更好地了解CAF对PDAC主要特征的影响将突出这些靶向细胞的诊断和治疗价值。
Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most challenging lethal tumors and has a very poor prognosis. In addition to cancer cells, the tumor microenvironment created by a repertoire of resident and recruited cells and the extracellular matrix also contribute to the acquisition of hallmarks of cancer. Among these factors, cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment. CAFs originate from the activation of resident fibroblasts and pancreatic stellate cells, the differentiation of bone marrow-derived mesenchymal stem cells and epithelial-to-mesenchymal transition. CAFs acquire an activated phenotype via various cytokines and promote tumor proliferation and growth, accelerate invasion and metastasis, induce angiogenesis, promote inflammation and immune destruction, regulate tumor metabolism, and induce chemoresistance; these factors contribute to the acquisition of major hallmarks of PDAC. Therefore, an improved understanding of the impact of CAFs on the major hallmarks of PDAC will highlight the diagnostic and therapeutic values of these targeted cells.