Prevalence of renal artery stenosis in diabetes mellitus — an autopsy study
Prevalence of renal artery stenosis in diabetes mellitus — an autopsy study
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糖尿病患者肾动脉狭窄的患病率——一项尸检研究
DOI：
10.1111/j.1365-2796.1991.tb00382.x
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发表时间：
1991
影响因子：
11.1
通讯作者：
M. Berger
中科院分区：
文献类型：
--
作者：
P. Sawicki;S. Kaiser;L. Heinemann;H. Frenzel;M. Berger
抽象。糖尿病患者肾动脉狭窄的患病率尚不清楚，因为没有无创和有效的筛查程序。因此，我们评估了5194例连续尸检协议，从1980年至1988年之间死亡的患者。此外，对肾动脉狭窄（RAS）患者的所有可用临床记录和随机样本进行了评价。研究发现，73%的RAS患者患有高血压，53%患有糖尿病，除1例外，所有患者均为2型（非胰岛素依赖型）。所有患者中有225例（4.3%）存在肾动脉狭窄[95%置信区间（95% CI），3.8-4.9]，93%的病例未在患者的临床记录中报告。所有糖尿病患者中有8.3%（95% CI，6.8- 9.8%）存在RAS，比值比为3.5（95% CI，2.6-4.6）。糖尿病合并高血压患者肾动脉狭窄发生率为10.1%。43%的RAS合并糖尿病患者和30%的非糖尿病RAS患者发现双侧肾动脉狭窄（P = 0.059）。我们的研究结果表明，肾动脉狭窄往往在尸检前未被发现。非胰岛素依赖型糖尿病的存在会增加肾动脉狭窄的风险。糖尿病患者双侧肾动脉狭窄的风险更大。这些结果可能对高血压非胰岛素依赖型糖尿病患者的诊断评估和降压治疗的选择具有重要意义。
Abstract. The prevalence of renal artery stenosis in diabetic patients is unknown, since no noninvasive and valid screening procedures are available. We have therefore evaluated 5194 consecutive autopsy protocols from patients who died between 1980 and 1988. In addition, all available clinical records for patients with renal artery stenosis (RAS) and a random sample were evaluated. It was found that 73% of patients with RAS were hypertensive, and 53% had diabetes, all but one being Type 2 (non‐insulin‐dependent). Renal artery stenosis was present in 225 (4.3%) of all patients [95% confidence interval (95% CI), 3.8–4.9], and was not reported in the patients' clinical records in 93% of cases. RAS was present in 8.3 % of all diabetic patients (95% CI, 6.8–9.8 %), the odds ratio being 3.5 (95% CI, 2.6–4.6). The frequency of renal artery stenosis in diabetic patients with hypertension was 10.1 %. Bilateral renal artery stenosis was found in 43% of patients with RAS and diabetes, and in 30% of non‐diabetic patients with RAS (P = 0.059). Our results indicate that renal artery stenosis often goes undetected before autopsy. The presence of non‐insulin‐dependent diabetes mellitus increases the risk of renal artery stenosis. The risk of bilateral renal artery stenosis is greater in diabetic patients. These results may be of significance with regard to the diagnostic evaluation and choice of antihypertensive treatment in hypertensive non‐insulin‐dependent diabetic patients.
糖尿病对严重慢性心力衰竭患者转换酶抑制引起的左心室性能和肾功能变化的影响。
DOI：
10.1016/0002-9343(87)90213-0
发表时间：
1987
期刊：
The American journal of medicine
影响因子：
--
作者：
Packer,M;Lee,WH;Medina,N;Yushak,M;Kessler,PD;Gottlieb,SS
通讯作者：
Gottlieb,SS