Elevated serum levels of interleukin-12 in chronic progressive multiple sclerosis
Elevated serum levels of interleukin-12 in chronic progressive multiple sclerosis
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DOI：
10.1016/s0165-5728(96)00101-4
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发表时间：
1996-10-01
影响因子：
3.3
通讯作者：
Reggio, A
中科院分区：
文献类型：
--
作者：
Nicoletti, F;Patti, F;Reggio, A
通过固相ELISA测定一组健康受试者、具有继发性慢性进展性疾病过程的多发性硬化（MS）患者和患有其他神经系统疾病（OND）的患者中异二聚体细胞因子IL-12的血清水平。血清IL-12水平高于5 pg/ml（检测灵敏度的极限）仅见于2/30例健康受试者（6.7%），而8例OND受试者中无一例。相比之下，在大多数CPMS患者的血清中发现IL-12（10/15，66.7%），其值在5.5和18.6pg/ml之间。这些结果提示CPMS中IL-12的产生上调。
The serum levels of the heterodimeric cytokine IL-12 were measured by solid-phase ELISA in a group of healthy subjects, multiple sclerosis (MS) patients with secondary chronic progressive course of the disease and patients suffering from other neurological diseases (OND). Serum levels of IL-12 higher than 5 pg/ml (limit of sensitivity of the assay) were only found in 2/30 (6.7%) of the healthy subjects and none of the 8 subjects with OND. In contrast, IL-12 was found in the majority of CPMS patients' sera (10/15, 66.7%) with values ranging between 5.5 and 18.6 pg/ml. These results are suggestive for an up-regulated production of IL-12 in CPMS.