Treatment of allergic asthma: modulation of Th2 cells and their responses.
Treatment of allergic asthma: modulation of Th2 cells and their responses.
复制标题
DOI：
10.1186/1465-9921-12-114
复制
发表时间：
2011-08-25
影响因子：
5.8
通讯作者：
Epstein MM
中科院分区：
文献类型：
--
作者：
Bosnjak B;Stelzmueller B;Erb KJ;Epstein MM
特应性哮喘是一种慢性炎症性肺部疾病，以反复发作的喘息、呼吸困难为特征，并在呼吸道内产生潜在的Th2细胞介导的炎症反应。根据病情的严重程度，目前的治疗方法是使用支气管扩张剂，例如长效的β-受体激动剂和长效的M受体拮抗剂，或使用抗炎药物，如皮质类固醇(吸入或口服)、白三烯调节剂、茶碱和抗IgE治疗。不幸的是，这些治疗都不是治愈的，一些哮喘患者对强烈的抗炎治疗没有反应。此外，长期使用口服类固醇有许多不良副作用。为此，需要新的、更有效的药物。在这篇综述中，我们重点介绍了CD4+Th2细胞及其产物作为开发新药的靶点，将其添加到现有的辅助药物或作为潜在的单独治疗过敏性哮喘的药物。我们认为，在早期疾病中，过敏原特异性Th2细胞的减少或消除将减少反复的过敏性炎症反应的后果，如肺重塑，而不会引起全身性免疫抑制。
Atopic asthma is a chronic inflammatory pulmonary disease characterised by recurrent episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory response in the airways. It is currently treated and, more or less, controlled depending on severity, with bronchodilators e.g. long-acting beta agonists and long-acting muscarinic antagonists or anti-inflammatory drugs such as corticosteroids (inhaled or oral), leukotriene modifiers, theophyline and anti-IgE therapy. Unfortunately, none of these treatments are curative and some asthmatic patients do not respond to intense anti-inflammatory therapies. Additionally, the use of long-term oral steroids has many undesired side effects. For this reason, novel and more effective drugs are needed. In this review, we focus on the CD4+ Th2 cells and their products as targets for the development of new drugs to add to the current armamentarium as adjuncts or as potential stand-alone treatments for allergic asthma. We argue that in early disease, the reduction or elimination of allergen-specific Th2 cells will reduce the consequences of repeated allergic inflammatory responses such as lung remodelling without causing generalised immunosuppression.
登录
查看更多内容
DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
4.4
作者：
Angeli, W;Hammad, H;Trottein, F
通讯作者：
Trottein, F
影响因子：
15.9
作者：
Blackburn, MR;Lee, CG;Elias, JA
通讯作者：
Elias, JA
DOI：
10.1164/rccm.200702-334oc
发表时间：
2007-11-15
影响因子：
24.7
作者：
Alcorn, John F.;Rinaldi, Lisa M.;Irvin, Charles G.
通讯作者：
Irvin, Charles G.
DOI：
10.1016/j.jaci.2007.10.028
发表时间：
2008-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Brightling C;Berry M;Amrani Y
通讯作者：
Amrani Y