Neolemnane-type sesquiterpenoids from a Formosan soft coral Paralemnalia thyrsoides
Neolemnane-type sesquiterpenoids from a Formosan soft coral Paralemnalia thyrsoides
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DOI：
10.1248/cpb.55.876
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发表时间：
2007-06-01
影响因子：
1.7
通讯作者：
Sheu, Jyh-Horng
中科院分区：
文献类型：
--
作者：
Huang, Ho-Cheng;Chao, Chih-Hua;Sheu, Jyh-Horng
从软珊瑚Paralemnalia thyrsoides的乙酸乙酯萃取物中分离得到六个新的倍半萜类化合物，命名为Eschemnolins D-I（1-6）。通过广泛的光谱分析以及将其光谱数据与相关代谢物的光谱数据进行比较，确定了这些代谢物的结构。这些代谢产物的绝对立体化学是通过应用Mosher方法和以前从Paralemnalia和Lemnalia属的软珊瑚中分离的其他相关化合物的绝对结构的基础上建立的。还报道了这些代谢物对有限的一组癌细胞系的细胞毒性。
Six new sesquiterpenoids, paralemnolins D-I (1-6), have been isolated from the EtOAc extract of the soft coral Paralemnalia thyrsoides. The structures of these metabolites were determined by extensive spectroscopic analysis and by comparison of their spectral data with those of related metabolites. The absolute stereochemistry of these metabolites was established by application of the Mosher's method on I and on the basis of the absolute structures of other related compounds previously isolated from the soft corals of the genera Paralemnalia and Lemnalia. Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is reported.