Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs.
Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs.
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卵清蛋白致敏改变了豚鼠对化学挑战的通气反应。
DOI：
10.1152/japplphysiol.00613.2005
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Lee,Lu-Yuan
中科院分区：
文献类型：
--
作者：
Xu,Fadi;Zhuang,Jianguo;Zhou,Tongrong;Lee,Lu-Yuan
Patients with chronic bronchial asthma show a depressed ventilatory response to hypoxia (DVH), but the underlying mechanism remains unclear. We tested whether DVH existed in ovalbumin (Ova)-treated guinea pigs, an established animal model of asthma. Twelve guinea pigs were exposed to Ova (1% in saline) or saline aerosol (control) for 5 min, 5 days/wk, for 2 wk. After completing aerosol exposure, the animals were anesthetized and exposed to systemic hypoxia. Ova treatment had no effects on animal body weight, baseline cardiorespiratory variables, or arterial blood O2and CO2tensions, but it attenuated the ventilatory response to hypoxia (10 breaths of pure N2) by 65% (P< 0.05). When the animals were subjected to intracarotid injections of sodium cyanide (20 μg) and doxapram (2 mg) to selectively stimulate carotid chemoreceptors, the ventilatory responses were reduced by 50% (P< 0.05) and 74% (P< 0.05), respectively. In contrast, Ova exposure failed to affect the ventilatory response to CO2(7% CO2-21% O2-balance N2for 5 min;P> 0.05). Furthermore, the apneic response evoked by stimulating bronchopulmonary C fibers (PCFs) with right atrial injection of capsaicin (5 μg) was markedly increased in the Ova-sensitized group (5.02 ± 1.56 s), compared with the control group (1.82 ± 0.45 s;P< 0.05). These results suggest that Ova sensitization induces a DVH in guinea pigs, which probably results from an attenuation of the carotid chemoreceptor-mediated ventilatory excitation and an enhancement of the PCF-mediated ventilatory inhibition.
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影响因子：
15
作者：
H. Kessler;M. Bernd;H. Kogler;J. Zarbock;O. Soerensen;G. Bodenhausen;R. R. Ernst
通讯作者：
R. R. Ernst
SMS 201-995，一种非常有效的生长抑素类似物。
DOI：
10.1111/j.1399-3011.1985.tb02217.x
发表时间：
2009
期刊：
International journal of peptide and protein research
影响因子：
--
作者：
C. Wynants;G. Van Binst;H. Loosli
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DOI：
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发表时间：
2009
期刊：
International journal of peptide & protein research
影响因子：
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J. Kobayashi;T. Higashijima;S. Sekido;T. Miyazawa
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影响因子：
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作者：
C. Wynants;G. Van Binst
通讯作者：
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DOI：
10.1111/j.1399-3011.1982.tb02663.x
发表时间：
2009
期刊：
International journal of peptide and protein research
影响因子：
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作者：
F. de Leeuw;C. Altona
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C. Altona