Total and Specific Polyphenol Intakes in Midlife Are Associated with Cognitive Function Measured 13 Years Later
Total and Specific Polyphenol Intakes in Midlife Are Associated with Cognitive Function Measured 13 Years Later
复制标题
DOI：
10.3945/jn.111.144428
复制
发表时间：
2012-01-01
影响因子：
4.2
通讯作者：
Galan, Pilar
中科院分区：
文献类型：
--
作者：
Kesse-Guyot, Emmanuelle;Fezeu, Leopold;Galan, Pilar
多酚，尤其是类黄酮，是一种无处不在的植物食物成分，具有可能有益于大脑健康的生化特性。我们试图评估总多酚摄入量和特定班级多酚摄入量与认知表现之间的长期联系。多酚摄入量是使用Phenol-Explorer数据库估计的，该数据库适用于1994-1996年间收集的至少6个24小时饮食记录，作为SU.VI.MAX(补充维生素和Mineraux抗氧剂)研究的一部分。本研究采用语音和语义流畅性、RI-48线索回忆测验、连线测验、前后向数字广度四种神经心理学测验对2574名中年人的认知能力进行了评估。用主成分分析估计测试分数之间的相互关系。多酚摄入量与认知之间的关系通过多元线性回归和方差分析进行评估。在多变量模型中，总多酚摄入量高与较好的语言和言语记忆相关(P=0.01)，但与执行功能无关(P=0.09)。更具体地说，儿茶素(P=0.001)、茶黄素(P=0.002)、黄酮醇(P=0.002)和羟基苯甲酸(P=0.0004)的摄入量与语言和言语记忆呈正相关，特别是与RI-48测试评估的情景记忆呈正相关。相反，执行功能得分与二氢查尔酮(P=0.01)、儿茶素(P=0.01)、原花青素(P=0.01)和黄酮醇(P=0.01)的摄入量呈负相关。大量摄入特定的多酚类物质，包括黄酮类和酚酸，可能有助于保存语言记忆，这是大脑病理性衰老中一个显著的脆弱领域。需要进一步调查，以澄清观察到的与执行职能有关的负面联系。J.Nutr.142：76-83,2012。
Polyphenols, and in particular flavonoids, are omnipresent plant-food components displaying biochemical properties possibly beneficial to brain health. We sought to evaluate the long-term association between total and class-specific polyphenol intake and cognitive performance. Polyphenol intake was estimated using the Phenol-Explorer database applied to at least six 24-h dietary records collected in 1994-1996 as part of the SU.VI.MAX (Supplementation en Vitamines et Mineraux Antioxydants) study. The cognitive performance of 2574 middle-aged adults participating in the cohort was assessed in 2007-2009 using the following four neuropsychological tests: phonemic and semantic fluency, the RI-48 Cued Recall test, the Trail Making test, and Forward and Backward Digit Span. Inter-correlations among the test scores were estimated with principal component analysis. Associations between polyphenol intake and cognition were assessed by multivariate linear regression and ANCOVA. In multivariate models, high total polyphenol intake was associated with better language and verbal memory (P = 0.01) but not with executive functioning (P = 0.09). More specifically, intake of catechins (P = 0.001), theaflavins (P = 0.002), flavonols (P = 0.01), and hydroxybenzoic acids (P = 0.0004) was positively associated with language and verbal memory, especially with episodic memory assessed by the RI-48 test. In contrast, negative associations between scores on executive functioning and intake of dihydrochalcones (P = 0.01), catechins (P = 0.01), proanthocyanidins (P = 0.01), and flavonols (P= 0.01) were detected. High intake of specific polyphenols, including flavonoids and phenolic acids, may help to preserve verbal memory, which is a salient vulnerable domain in pathological brain aging. Further investigations are needed to clarify the observed negative associations regarding executive functioning. J. Nutr. 142: 76-83, 2012.